家兔静脉注射头孢哌酮钠/舒巴坦钠后房水玻璃体药浓度检测  

Detection of cefoperazone/sulbactam in rabbit aqueous vitreous after intravenons injection

作　　者：付竞[1] 陈雪艺[1] 赵菊芳[1] 

机构地区：[1]新疆医科大学第一附属医院眼科

出　　处：《国际眼科杂志》2009年第6期1075-1076,共2页International Eye Science

摘　　要：目的:研究家兔静脉注射头孢哌酮钠/舒巴坦钠在眼内的透过性及蓄积作用。方法:用高效液相色谱法(high performance liquid chroma-tography,HPLC)测定给药后不同疗程时间点各组兔眼房水和玻璃体中的药物浓度。结果:房水中舒巴坦钠的药物浓度分别为23.4±4.8和23.6±3.7mg/L;头孢哌酮钠浓度分别为8.9±1.2和8.9±1.7mg/L;玻璃体中舒巴坦钠浓度分别为71.2±4.6和69.3±6.8mg/L,头孢哌酮钠未检出。结论:头孢哌酮钠/舒巴坦钠静脉注射后在正常的眼内透过性不良。AIM： To measure ocular tissue permeability and accumulation of cefoperazone/sulbactam in rabbit after intravnous injection. METHODS： The different groups of rabbit intraocular aqueous fluid and vitreous body concentrations of cefoperazone/sulbactam at different times were measured by high performance liquid chromatography. RESULTS：The concentrations of sulbactam in aqueous humor were 23.4 ±4.8 and 23.6 ± 3. 7mg/L, and cefoperazone were 8.9 ± 1.2 and 8.9± 1.7mg/L; The concentrations of sulbactam in vitreous body were 71.2 ± 4.6 and 69.3 ± 6.8mg/L, and cefoperazone was too little to be measured. CONCLUSION： Cefoperazone/sulbactam showed bad penetration when administrated by intravenous injection in the normal eye, and could not maintain therapeutic levels in intraocular tissue. Also, both of them didn＇t manifest significant accumulation.

关 键 词：头孢哌酮钠/舒巴坦钠 高效液相色谱法 药物浓度 

分 类 号：R96[医药卫生—药理学]