正常高值血压患者血清内皮素、一氧化氮与炎性因子水平变化及其意义  

Levels of Serum Endothelin and Other Inflammatory Factors in Prehypertension and Hypertension Patients

作　　者：唐蕊[1] 李海涛[2] 马文君[3] 孙绍贤 

机构地区：[1]唐山工人医院分院心内科,河北省唐山市063000 [2]华北煤炭医学院附属医院心内科 [3]中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院高血压诊治中心 [4]秦皇岛妇幼保健医院内科

出　　处：《中国循环杂志》2009年第3期210-212,共3页Chinese Circulation Journal

摘　　要：目的:观察正常高值血压患者血清内皮素、一氧化氮及炎性因子水平的变化,并探讨其在高血压治疗和预防方面的意义。方法:从2007-06至2007-09在唐山铁路中心医院进行健康查体的3050名铁路职工中按照美国高血压预防、诊断、评价与治疗联合委员会的第7次报告(简称JNC7)诊断标准筛选出106例正常高值血压患者(正常高值组),91例原发性高血压患者(高血压组),同时随机挑选98例血压正常健康人作为正常对照组。分别采用放射性免疫法和生化法测定血清中内皮素(ET)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)的含量。结果:3组患者血清内皮素、一氧化氮、TNF-α及IL-6的变化:与正常对照组比较正常高值组和高血压组的血清内皮素、一氧化氮(除外高血压组降低)、TNF-α及IL-6水平均升高,差异均有统计学意义(P<0.05)。正常高值血压危险因素的多因素Logistic回归分析:以正常高值血压为应变量,其他指标为自变量进行多因素Logistic回归,正常高值血压与体重指数、内皮素、一氧化氮、TNF-α、IL-6呈正相关。结论:正常高值血压患者血清内皮素、一氧化氮、TNF-α、IL-6及体重指数出现了异常变化,提示它们与正常高值血压有关。Objective：To observe the levels of serum endothelin（ ET）, nitric oxide （NO）, tumor necrosis factor-α （TNF-α）and interlenkin-6（IL-6） in prehypertension and hypertension patients. Methods ：Three groups were recruited from 3050 subjects of regular health checkup in Tangshan Railway Hospital from June to September,2007. Prehypertension （PH） group： n =106, Essential hypertension （EH） group： n = 91, and Normotensive （NT） control group： n = 98. The levels of ET,TNF-α, IL-6 and NO were compared by radioimmunoassay and biochemical tests. Results： （1）Compared with NT group, body mass index （BMI） and serum lipids （TC, TG, LDL-C ） were significantly increased in PH and EH groups （P 〈 0. 05 ）, high-density lipoprotein cholesterol （HDL-C） was decreased in EH groups （ 1.59 ± 0. 15 vs. 1.77 ± 0. 19, P 〈 0.05 ）. （1）Compared with NT group, ET, IL-6, TNF-α were increased in PH and EH groups （P 〈 0. 05）. NO was increased in PH group （6. 55 ±0.94 vs. 5.87 ±0. 80,P 〈0.05） while decreased in EH group （5.28±0. 81 vs. 5.87 ± 0. 80, P 〈 0.05 ）. （3）Logistic analysis indicated that BMI, ET, NO ,TNF-α and IL-6 were related to the hypertension. Conclusion： ET,NO,TNF-α,IL-6 were elevated in prehypertension patients and those might be used to predict the risk of hypertension.

关 键 词：正常高值血压 内皮素 一氧化氮 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R541[医药卫生—心血管疾病]