雌四醇的研究进展  

Major research advances in estetrol

作　　者：罗恋梅[1] 田秦杰[1] 徐苓[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院妇产科,北京100730

出　　处：《生殖医学杂志》2009年第3期305-308,共4页Journal of Reproductive Medicine

摘　　要：雌四醇(estetrol E_4)是一种仅由胎儿肝脏产生的类固醇激素。20世纪60到80年代对E_4的研究相对较多,普遍的观点认为它有弱的雌激素作用,但不能作为胎儿是否健康的监测指标之一。近20年以后对其的研究进入了低谷。近年E_4重又获关注。一系列关于E_4的临床前研究提示,E_4可用于围绝经期及绝经后激素替代、骨质疏松的防治及口服避孕药。但是关于E_4对人体各个器官系统的作用仍有待进一步的研究。本文就E_4的相关研究做一简要综述。Estetrol （E4） is a steroidal hormone, produced by the human fetal liver only. E4 was studied a lot from 1960s to 1980s. It seems likely that E4 has a weak estrogenic activity. But it can not be used as an effective indicator for monitoring the health condition of fetus. After 20 years of experimental work, E4 research was virtually abandoned. In recent years, based on new data, E4 catches our eyes again. A lot of preclinical studies indicated that E4 may be useful in the treatment of osteoporosis and hormone replacement therapy （HRT）, as well as in contraception. Therefore more clinical researches are needed to confirm these and other possible indications.

关 键 词：雌四醇 围绝经期 激素替代 

分 类 号：R714.51[医药卫生—妇产科学] R331.2[医药卫生—临床医学]