原发性甲功减退症患者治疗前后血脂、心肌酶谱的变化  

作　　者：吴正华[1] 

机构地区：[1]四川省资阳市第一人民医院内三科,641300

出　　处：《当代医学》2009年第18期7-8,共2页Contemporary Medicine

摘　　要：目的观察原发性甲状腺功能减退症(甲减)患者应用左旋甲状腺素(优甲乐)治疗后血脂、心肌酶谱的变化。方法40例明确诊断的甲状腺功能减退症患者进行甲状腺激素替代治疗,观察治疗前后血脂、心肌酶谱的改变。结果治疗前,TC、LDL-C水平与FT3、FT4、TSH水平显著相关,而TG水平未表现出与甲状腺功能有相关性;心肌酶水平与甲状腺功能显著相关。治疗后,甲状腺功能逐渐恢复正常,TC、LDL-C、心肌酶谱均明显下降。结论原发性甲减患者应用左旋甲状腺素治疗后可显著降低TC、LDL-C及心肌酶谱水平。Objective To evaluate the changes in blood lipids, myocardial enzymes after levothyroxine treatment in the patients with primary hypothyroidism. Methods Forty hypothyroidism patients were given the treatment of thyroid gland hormone, the changes of the myocardial enzyme before and after the treatment were observed. Results Before treatment, TC and LDL-C levels were significantly correlated with FT3, FT4 and TSH levels, meanwhile, TG leve was not associated with thyroid function. In addition, CK, AST, LDH and HBDH levels were significantly correlated with thyroid function. After treatment, thyroid function gradually improved to normal. TC, LDL-C myocardial enzymes were significantly decreased. Conclusion The administration of levothyroxine to patients with primary hypothyroidism can increase the level of myocardial enzymes and decrease significantly the level of TC and LDL-C.

关 键 词：甲状腺功能减退症 血脂 心肌酶谱 

分 类 号：R581.2[医药卫生—内分泌] R749.3[医药卫生—内科学]