妊娠期糖代谢异常患者产后6～12周糖代谢转归的随访研究  

A follow up study on outcomes of abnormal glucose metabolism during pregnancy at 6-12 weeks postpartum

作　　者：吴红花[1] 孙伟杰[2] 惠岩[1] 李正敏[2] 杨慧霞[2] 郭晓蕙[1] 

机构地区：[1]北京大学第一医院内分泌科,100034 [2]北京大学第一医院产科,100034

出　　处：《中国糖尿病杂志》2009年第6期466-469,共4页Chinese Journal of Diabetes

摘　　要：目的探讨北京地区妊娠期糖代谢异常患者产后6～12周糖代谢转归。方法产后6～12周复诊女性193例(6例糖尿病妊娠,187例孕期糖代谢异常)。内分泌科与产科协作行妊娠糖尿病(GDM)随诊,询问体重变化,测腰围、臀围;行OGTT检测各时间点血糖和胰岛素;检测TG、TC、HDL-C、LDL-C。结果(1)产后6～12周26.2%存在糖耐量异常(IGT),2.1%发生T2DM。(2)22%存在高TG血症,45.7%高TC血症,55.3%高LDL-C血症。(3)多因素分析显示孕期需要应用胰岛素、产前BMI大、产后6～12周高TC血症及HDL-C水平偏低为产后糖代谢异常的危险因素。结论妊娠期糖代谢异常患者产后6～12周仍普遍存在糖代谢异常,应重视对这一群体的随访,预防或延缓其向T2DM的进展。Objective To follow up the outcome of patients who were diagnosed as GDM, and investigate how the abnormal glucose metabolism turns at 6-12 weeks postpartum in Beijing. Methods 193 patients who delivered from feberary 2007 to march 2008, had visited at 6-12 weeks after delivery. Six had diabetes with pregnancy, 187 had gestational abnormal glucose metabolism. We set up a clinic service for medical collaboration between Endocrinology .and Maternity Department, measured waist and hip circumference, and investigated oral glucose tolerance test（OGTT） and lipid profile. Results 1. Results revealed 26.2% cases with IGT and 2.1% with T2DM at 6-12 weeks postpartum. 2.22% cases occurred hypertriglyeeridemia, 45.7% hypercholesterolemia, 55.3% higher low density lipoprotein. 3. Correlation analysis revealed that insulin treatment during pregnancy, an increased antepartum body mass index, and hypercholesterolemia at 6-12 weeks postpartum were the risk factors of postpartum glucose intolerance. Conclusions There were generally glucose intolerance at 6-12 weeks postpartum in patients with abnormal glucose metabolism during pregnancy. As a group, they are worthy of long-term follow up to prevent or retard the progress to T2DM.

关 键 词：妊娠糖尿病 糖尿病 2型 产后 随访 

分 类 号：R714.25[医药卫生—妇产科学]