mazEF系统介导胁迫诱导细菌细胞程序性死亡  

Bacterial Programmed Cell Death Mediated by mazEF System Under Stressful Conditions

作　　者：庄强[1,2] 宁德刚[1] 

机构地区：[1]江苏大学环境学院,江苏镇江212013 [2]江苏大学生命科学研究院,江苏镇江212013

出　　处：《微生物学通报》2009年第6期905-909,共5页Microbiology China

基　　金：国家自然科学基金项目(No30771176)

摘　　要：mazEF是细菌染色体上的"毒素-抗毒素系统"基因(Toxin-antitoxin system,TA系统),可介导胁迫诱导细菌细胞程序性死亡。本文介绍了mazEF系统的遗传结构特征、生理生化功能、环境胁迫激活mazEF系统介导的细菌细胞程序性死亡的机制,参与细胞死亡过程中的细胞信号和细胞因子的调控,以及关于mazEF系统介导的细菌细胞程序性死亡理论的争论,提出了进一步丰富和完善细菌细胞程序性死亡理论亟待解决的问题。mazEF, which is a toxin-antitoxin system located in bacterial chromosome, can mediate programmed cell death induced by various stressful conditions. In this review, the genetic structure, physiological and biochemical function of mazEF system were outlined, cellular signals and the regulation of cell factors involved in the process of cell death were introduced, and the controversy on the theory of mazEF-mediated programmed cell death was discussed. Based on the present results, It is pointed out that some questions about bacterial programmed cell death should be taken into more consideration.

关 键 词：毒素-抗毒素系统 mazEF基因 环境胁迫 细菌细胞程序性死亡 

分 类 号：Q2[生物学—细胞生物学]