黄精皂苷对抑郁模型小鼠行为及脑内单胺类神经递质的影响  

Effects of Saponins of Rhizoma polygonati on behaviors and monoamine neuro-transmitters in mice depression model

作　　者：耿甄彦[1] 徐维平[1,2] 魏伟[1] 陈辰[1] 徐婷娟[2] 

机构地区：[1]安徽医科大学临床药理研究所,合肥230032 [2]安徽医科大学附属省立医院,合肥230001

出　　处：《中国新药杂志》2009年第11期1023-1026,共4页Chinese Journal of New Drugs

摘　　要：目的:研究黄精皂苷对抑郁小鼠行为学及脑内单胺类神经递质(NE,DA和5-HT)的影响。方法:以孤养加慢性不可预见性刺激进行抑郁症小鼠造模,将小鼠分为空白组、模型组、对照组和三个剂量的黄精皂苷组(100,200,400 mg.kg-1),并进行自主活动测定、水迷宫试验以及脑内单胺类神经递质含量的测定。结果:模型组小鼠的自主活动、学习记忆能力以及脑内的单胺类神经递质含量均明显下降。黄精皂苷各剂量组能显著提高抑郁小鼠的自主活动和学习记忆能力,同时增加抑郁小鼠脑内单胺类神经递质含量。结论:黄精皂苷能够纠正抑郁症小鼠行为学变化,并且能够提高脑内NE,DA,5-HT的含量。Objective ： To investigate the effects of saponins of Rhizoma polygonati on behaviors and monoamine neuro-transmitters（NE,DA and 5-HT） in mice depression model. Methods： The depression disorder mice model was established by the CUMS and solitary custody. The mouse were divided into 4 groups： normal group, model group, control group and treatment groups with saponins of Rhizoma polygonati （100, 200, 400 mg· kg^-1）. The autonomous activity, water maze test, and monoamine neurotransmitter were determination. Results： The autonomous activities and the memory of the model group were decreased obviously, and the contents of monoamine neuro-transmitters in the brain had the same effects. The saponins of Rhizoma polygonati increased the autonomic activities and the memory capability significantly; the content of monoamine neuro-transmitters in the brain was increased. Conclusions： The saponins of Rhizoma polygonati can improve the diversify of the behaviors and elevate the contents of the NE, DA and 5-HT in the brain of the depressive disorder mouse model.

关 键 词：黄精皂苷 抑郁症 行为学 单胺类神经递质 

分 类 号：R971.43[医药卫生—药品]