乌头急性中毒死亡者乌头生物碱的体内分布  

Distribution of Aconitum Alkaloids in the Corpse Died of Acute Aconite Intoxication

作　　者：刘伟[1,2] 沈敏[2] 秦志强[2] 

机构地区：[1]复旦大学上海医学院法医学系,上海200032 [2]司法部司法鉴定科学技术研究所上海市法医学重点实验室,上海200063

出　　处：《法医学杂志》2009年第3期176-178,共3页Journal of Forensic Medicine

基　　金：中央级公益性科研院所科研专项基金资助项目(GY0702);上海市科委资助项目(072512019)

摘　　要：目的研究乌头急性中毒死亡者体液和组织中乌头生物碱的分布,为乌头中毒案的法医学鉴定取材和结果评价提供参考。方法用液相色谱-串联质谱法测定中毒死亡者体液和组织中乌头生物碱的含量。结果乌头碱在死者体液和组织中的含量从大到小依次为尿液、胆汁、胃内容物、心血、胰、心、肠、肝、肾、胃、肺、胆囊、脾,脑中未检出。结论尿液、胆汁和血液是检测体内乌头生物碱的较佳检材。Objective To investigate the distribution of aconite alkaloids in biological fluids and tissues in the corpse died of acute aconite intoxication and to provide information for sample selection and result evaluation in forensic identification. Methods The content of aconite alkaloids in biological fluids and tissues were determined by liquid chromatography-tandem mass spectrometry. Results The content of aconite displayed in decending order of urine, bile, gastric content, heart blood, pancreas, heart, intestine, liver, kidney, stomach, lung, gallbladder and spleen, with no aconite detected in the brain. Conclusion It was indicated that urine, bile and blood are the best specimens for the determination of aconite in body of the acute aconite intoxication.

关 键 词：法医毒理学 乌头生物碱 液相色谱-串联质谱法 体内分布 

分 类 号：R285.5[医药卫生—中药学] R595[医药卫生—中医学]