血液CPR、IL-6和纤维蛋白原动态检测与不稳定心绞痛患者预后的关系  

Relations of Dynamic Detection of CPR,IL-6 and Fibrinogen in Blood with Prognosis of Patients with Unstable Angina

作　　者：张洪[1] 

机构地区：[1]鹤壁市鹤壁煤业集团总医院检验科

出　　处：《医学综述》2009年第13期2052-2054,共3页Medical Recapitulate

摘　　要：目的探讨血液C反应蛋白（CRP）、白细胞介素6（IL-6）和纤维蛋白原（Fib）动态检测在稳定心绞痛（UAP）患者中的应用及其与患者预后的关系。方法93例UAP患者作为观察组，40例体检健康者为对照组，分别在入院和出院时采血检测CPR、IL-6和Fib，分析各组结果，并对出院患者随访6个月，观察心脏事件发生情况。结果UAP患者入院时CPR、IL-6和Fib水平显著高于对照组（P〈0．05或P〈0．01），随着患者危险分级的递增其水平递增；出院时CPR、IL-6和Fib仍然高于对照组，患者心脏事件发生率显著高于正常患者（P〈0．05）。结论血液CPR、IL-6和Fib的动态变化与IIAP摩者的佰除弁级砖苴而后右一串姜桑．Objective To investigate the application of dynamic testing of C-reactive protein（CRP） ,interleukin-6（ IL-6 ）and fihrinogen（ Fib ）in blood of patients with unstable angina（UAP） and its relationship with their prognosis. Methods 93 cases with UAP was observation group, 40 healthy eases was control group, CPR, IL-6 and Fib in blood were detected during administration and discharge. All the results were analyzed. Besides that, all the discharged patients were followed up for 6 months to observe the occurrence of heart event. Results As for patients with UAP in admission, the levels of CPR,IL-6 and Fib were significandy higher than those of controls（P 〈0.05 or P 〈0.01 ） ; the higher the risk grade of patients,the higher the level of these indexes. The incidence of cardiac events and levels of CPR, IL-6 and Fib also is elevated in discharged patients were also significantly higher than that of normal patients （ P 〈 0.05 ）. Conclusion Dynamically changed levels of CPR,IL-6 and Fib in blood of patients with UAP is elosey associated with the risk classification and prognosis of patients with UAP.

关 键 词：不稳定性心绞痛 C反应蛋白 白细胞介素6 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]