注射用盐酸米诺环素在健康人体的药物动力学  

Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers

作　　者：高守红[1] 温燕[1] 邬蓉[1] 金晓玲[1] 恽芸蕾[1] 李静娴[1] 缪海均[1] 

机构地区：[1]第二军医大学附属长征医院药材科,上海200003

出　　处：《药学实践杂志》2009年第3期193-194,200,共3页Journal of Pharmaceutical Practice

摘　　要：目的:研究注射用盐酸米诺环素在健康人体内的药物动力学。方法:10名健康志愿者单剂量静脉滴注200 mg注射用盐酸米诺环素,采用HPLC测定血浆中米诺环素浓度,计算药动学参数。结果:10例健康受试者单剂量静脉滴注200 mg盐酸米诺环素,主要药动学参数t1/2为(18.1±4.07)h;Cmax为(4.744±0.887)mg/L;tmax为2.0 h;AUC0→72h为(75.71±10.68)mg.h/L;AUC0→∞为(79.90±12.81)mg.h/L。结论:受试制剂注射用盐酸米诺环素在人体内的药代动力学特征与文献报道一致。Objective： To study the pharmacokinetics of minocycline hydrochloride in 10 Chinese healthy volunteers after a single intravenous administration of 200mg minocycline. Methods： Minoeycline hydroehloride concentration in plasma was measured by an improved HPLC method, and the pharmacokinetic parameters were calculated. Results： After single dose administration of 200 mg minocyeline, the main pharmaeokinetie parameters t1/2, C max, tmax, AUC0→72h , AUC0→∞ were （18.1 ±4.07） h, （4. 744 ± 0. 887） mg/L, 2.0 h, （75.71 ± 10.68） mg.h/L, （79.90 ± 12.81 ）mg.h/L, respectively. Conclusion：The main pharmaeokinetie parameters of minocycline are consistent with those reported previously.

关 键 词：盐酸米诺环素 HPLC 药代动力学 

分 类 号：R945[医药卫生—微生物与生化药学]