牙周病患者治疗前后血清IL-6、hs-CRP和唾液SIgA测定的临床意义  

Clinical Significance of Determination of Changes of Serum IL-6,hs-CRP and Saliva Secretory IgA Levels After Treatment in Patients with Periodontitis

作　　者：王统伍[1] 

机构地区：[1]连云港市第一人民医院口腔科,222002

出　　处：《放射免疫学杂志》2009年第3期211-213,共3页Journal of Radioimmanology

摘　　要：目的:探讨了牙周病患者治疗前后血清IL-6、hs-CRP和唾液SIgA水平的变化及临床意义。方法:应用放射免疫分析和免疫比浊法对42例牙周病患者进行了治疗前后血清IL-6、hs-CRP和唾液SIgA测定,并与35名正常健康人作比较。结果:在治疗前血清IL-6、hs-CRP和唾液SIgA水平均非常显著地高于正常人组(P<0.01),经系统治疗一个月后,除IL-6、hs-CRP水平与正常人组比较无显著差异外(P>0.05),唾液SIgA水平与正常人组比较仍有显著性差异(P<0.05)。结论:血清IL-6、hs-CRP和唾液SIgA水平在牙周病的发生、发展过程中的相互作用,观察其浓度的变化对探讨其发病机理、预防和指导用药均有重要的临床价值。Objective To explore the clinical significance of changes of serum IL - 6, ks - CRP and saliva secretory IgA levels after treatment in patients with periodontitis. Methods Serum IL - 6, saliva secretory IgA （ with RIA） and serum ks - CRP （ with immtmo - tarbility method） levels were measured in 42 patients with periodontitis both before and after treatment as well as in 35 con- trois. Results Before treatment serum IL - 6, ks - CRP and saliva secretory IgA levels in the patients wree significantly higher than those in controls （P 〈 0.01 ）. After treatment for one month the serum IL - 6, ks - CRP levels in the patients were not much different from those in controls （P 〉 0. 05）. However, the saliva secreatory IgA levels were still significantly higher than those in controls （P 〈 0.05）. Conclusion There was disturbance of immunomodulation in patients with periodontitis as expressed by the changes of cytokines levels in the course of the diseases.

关 键 词：牙周病 白细胞介素-6 超敏C-反应蛋白 分泌型免疫球蛋白A 

分 类 号：R581.1[医药卫生—内分泌] R179[医药卫生—内科学]