CHD患者血浆ET-1、GMP-140和血清cTnI检测的临床意义  

Clinical Significance of Determination of Plasma ET-1,GMP-140 and Serum cTnI Levels in Patients with Coronary Heart Disease

作　　者：苏焱伦 

机构地区：[1]连云港市中医院心内科,222001

出　　处：《放射免疫学杂志》2009年第3期216-218,共3页Journal of Radioimmanology

摘　　要：目的:探讨冠心病(CHD)患者血浆ET-1、GMP-140和血清心肌肌钙蛋白Ⅰ(cTnI)水平的变化及意义。方法:应用放射免疫分析和酶免法对96例CHD患者进行了血浆ET-1、GMP-140和血清cTnI水平的测定,其中稳定型心绞痛(SAP)36例,不稳定型心绞痛(UAP)41例,急性心肌梗死(AMI)19例。并与35例正常健康人作比较。结果:CHD患者血浆ET-1、GMP-140和血清cTnI水平均非常显著的高于正常人组(P<0.01),急性AMI组和UAP组又高于SAP组(P<0.05),且血清cTnI水平与血浆ET-1、GMP-140水平呈正相关。结论:检测CHD患者血浆ET-1、GMP-140和血清cTnI水平的变化对CHD的发生和发展以及疗效和预后观察均具有重要的临床意义。Objective To explore the clinical significance of changes of plasma ET - 1, GMP - 140 and serum eTnI levels in patients with CHD. Methods Plasma ET - 1, GMP - 140 levels （with RIA） and serum cTnI levels （with ELISA） were determined in 96 patients with CHD （36 SAP, 41UAP, 19AMI） and 35 controls. Results Plasma ET - 1, GMP - 140 and serum cTnI levels in patients with CHD were significantly higher than those in controls （ P 〈 0.01 ）. Among the CHD patients, magnitidue of changes of the levels of plasma ET - 1, GMP - 140 and serum cTnI in AMI and UAP groups were significantly larger than those in SAP groups （P 〈 0.05）. Serum cTnI levels were positively correlated with plasma ET - 1, GMP - 140 levels. Conclusion The plasma ET - 1, GMP - 140 and serum cTnI levels were closely related to the diseases process of CHD and were of great clinical importance.

关 键 词：冠心病 内皮素-1 肌钙蛋白-Ⅰ 颗粒膜蛋白-140 稳定型心绞痛 不稳定型心绞痛 急性心肌梗死 

分 类 号：R512.3[医药卫生—内科学] R541.4[医药卫生—临床医学]