术中内脏牵拉强度及持续时间对大鼠呼吸循环的影响  

Effect of Intensity and Time of Visceral Traction During Operation on the Respiration and Circulation in Rats

作　　者：焦赫娜[1] 蔡宏伟[1] 

机构地区：[1]中南大学湘雅医院麻醉科,湖南长沙410008

出　　处：《医学临床研究》2009年第6期963-965,共3页Journal of Clinical Research

摘　　要：【目的】观察手术中不同的内脏牵拉强度及持续时间与牵拉应激强度的关系。【方法】42只Wistar大鼠随机分为7组：A组牵拉10g砝码，1min。B组牵拉10g砝码，2min。C组牵拉20g，砝码1min。D组牵拉20g砝码，2min。E组牵拉30g砝码，1min。F组牵拉30g砝码，2min。G组为未牵拉对照组只完成麻醉与手术操作。观察大鼠牵拉前后呼吸循环的变化。【结果】牵拉时MAP的变化差值D、E、F组与A、B、C、G组间比较差异有显著性；A、B、C组与G组比较差异有显著性。牵拉前与牵拉时RR的差值在牵拉2min组（B、D、F组）与对照组G组间的比较差异有显著性，牵拉1min组（A、C、E组）与对照组G组间比较差异无显著性。【结论】①牵拉肠系膜的空肠动脉可复制临床牵拉动作，建立内脏牵拉应激强度模型；②增加牵拉强度和延长牵拉时间均可加重MAP的波动幅度，但MAP的变化与牵拉强度及牵拉时间为非线性的正比量效关系；③牵拉对呼吸的影响只有牵拉达一定时间才表现出来。[Objective] To investigate the effects of graded intensity and time of visceral traction during operation on respiration and circulation. [Methods] Forty-two healthy Wistar rats were randomly divided into 7 groups. Group A received traction with 10g for 1 min. Group B received traction with 10g for 2 min. Group C received traction with 20g for 1 min. Group D received traction with 20g for 2 min. Group E received traction with 30g for 1 min. Group F received traction with 30g for 2 min. Group G （control group） was only operated but not dragged. Mean arterial pressure （MAP）, heart rate （HR） and respiration rate （RR） were continuously monitored during experiment. [Results]There was significant difference in MAP between group D, E F and group A, B, C, G, and also between group A, B, C and group G. There was significant difference in RR between group B, D, F and group G, but there was no significant difference between group A, C, E and group G. [Conclusion]（1）Traction on the jejunal vessels of rats can copy clinical traction reactions and establish a model of visceral traction intensity. （2）The increase of the intensity and time of traction can elevate the fluctuation range of MAP, but there is non-linear positive relationship between MAP and intensity and time of traction. （3）The effect of traction on respiration is displayed only when the time of traction is enough.

关 键 词：内脏 呼吸系循环 大鼠 

分 类 号：R331.37[医药卫生—人体生理学]