心脂肪酸结合蛋白与传统血清标志物诊断急性心肌梗死超急性期的比较  

Comparison Between Heart-fatty Acid Binding Proteins and Traditional Serum Markers in Diagnosing the Super-acute Stage of Acute Myocardial Infarction

作　　者：邓胜林[1] 马有根[1] 刘志贤[1] 付林 袁光雄 

机构地区：[1]湖南省湘潭市第一人民医院,湖南湘潭411100 [2]湖南省湘潭市中心医院,湖南湘潭411100

出　　处：《医学临床研究》2009年第6期993-994,997,共3页Journal of Clinical Research

摘　　要：【目的】比较心脂肪酸结合蛋白（H—FABP）与肌红蛋白、CK—MB和肌钙蛋白I（cTnI）在诊断急性心肌梗死（AMI）早期的诊断价值。【方法】因胸痛1～2h急诊入院的患者（AMI21例，其他疾病引起胸痛44例）分别于胸痛症状发作1～2、3和6h采集血标本，20名年龄相匹配的正常对照于8am，10am和1pm采集血标本，采用酶联免疫吸附法（ELIA）检测H—FABP、肌红蛋白、CK—MB和cTnI。【结果1AM1组1～2和3h内采集的血标本H—FABP和肌红蛋白显著高于（P〈0．05）非AMI组和对照组。3h血标本cTnI在AMI组较非AMI组和对照组增高（P〈0．05），CK—MB在3h血标本中，AMI组高于对照组（P〈0．05），而与非AMI组差异无显著性（P〉0．05）。【结论】H—FABP在诊断AMI超急性期有重要的价值。[Objective] To compare the diagnostic value of heart-fatty acid binding proteins（H-FABP）, muscle hemoglobin, MB isoenzyme of creatine kinase （CK-MB） and treponin（CTnI） in diagnosing the earlier period of acute myocardial infarction（AMI）.[Methods] Sixty five patients of emergency hospitalization with 1 to 2 hours of pectoralgia （among of them, 21 pectoralgia due to AMI vs 44 pectoralgia due to other diseases, the group AMI vs the group non-AMI ） were studied. Blood samples were collected from all of these patients at the first or second, the third and the sixth hour after pectoralgia attack and another 20 patients matched in their age without pectoralgia whose blood samples were collected at 8 am, 10 am andl pm （the group control）. H-FABP, muscle hemoglobin, CK-MB and CTnI were detected by enzyme linked immunosorbent assay （ELIA） in all of the blood samples. [Results] H-FABP and muscle hemoglobin of the blood samples collected at the first to second and the third hour and CTnI collected at the third hour in the group AMI were higher than those in the group non-AMI and the group control（ P 〈0.05）. CK-MB collected at the third hour in the group AMI was also higher than that in the group control（ P 〈0.05）, however, there was no statistic difference between the group AMI and the group non-AMI（ P〉0.05）. [Conclusion]H-FABP is more valuable in diagnosing the super-acute stage of AMI.

关 键 词：心肌梗塞/诊断 肌酸激酶同工酶类/分析 

分 类 号：R542.22[医药卫生—心血管疾病]