替米沙坦联合辛伐他汀治疗早期糖尿病肾病疗效观察  

Observation of effects of telmisartan combined with simvastatin on diabetic nephropathy in the early stage

作　　者：刘青员[1] 徐昌辉[1] 徐书灿[1] 

机构地区：[1]江苏省滨海县人民医院内一科,224500

出　　处：《临床合理用药杂志》2009年第10期22-23,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察替米沙坦(美卡素)联合辛伐他汀治疗早期糖尿病肾病的治疗效果。方法将91例早期糖尿病肾病患者随机分为3组,常规组28例行常规治疗,替米沙坦组31例为替米沙坦加常规治疗,联合组32例为替米沙坦与辛伐他汀加常规治疗。疗程1个月,并监测尿β2微球蛋白、尿微量白蛋白。结果替米沙坦组及联合治疗组尿β2微球蛋白、尿微量白蛋白在治疗后明显下降;与常规治疗组比较差异有统计学意义(P<0.01);联合组与替米沙坦组比较,差异有统计学意义(P<0.05)。结论替米沙坦联合辛伐他汀可明显降低早期糖尿病肾病的尿白蛋白,防止病情进展。Objective To observe the effects of telmisartan combined with simvastatin on diabetic nephropathy in the early stage. Methods 91 cases with early diabetes nephrosis patient were randomly divided into the conventional group （ n = 28 ） with conventional treatment, the telmisartan group with telmisartan （n = 31 ）, the union group telmisartan and simvastatin （ n = 32 ）. The treatment course month, and monitors the urine β2 microballoons protein, the urine micro albumin. Results For the Mischa Tanzania group and union treatment group urine β2 microballoons protein, urine micro albumin droped obvious- ly after treatment compared with conventional group（ P 〈0.01 ）. And there was significant difference between t telmisartan group and union group（ P 〈 0.05 ）. Conclusion Telmisartan combined with simvastatin can obviously reduce the urine albu- min in patients with early diabetic nephropathy and prevent the progress of condition.

关 键 词：替米沙坦 辛伐他汀 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]