合江县及毗邻地区肺吸虫病流行病学调查——附肺吸虫病肝损害2例  

Paragonimiasis Skrjabini in Southern Sichuan Region—Epidemic Situation,and A Report of 2 Cases of Liver Damage by Paragonimiasis

作　　者：李珍炼[1] 牛慧[1] 张锡林[2] 王英[2] 陈文碧[1] 钱宝珍[3] Sugiyama H 王光西[1] 

机构地区：[1]泸州医学院病原生物学教研室,四川泸州646000 [2]第三军医大学病原生物学教研室 [3]浙江省医学科学院生物工程研究所 [4]日本国立感染病研究院

出　　处：《寄生虫病与感染性疾病》2009年第2期66-70,共5页Parasitoses and Infectious Diseases

基　　金：四川省教育厅科研基金(NO.2005A067);日本第二期健康科学基金(2007)

摘　　要：目的了解合江县及毗邻地区肺吸虫病流行现状。方法分部位解剖溪蟹并计算囊蚴感染率(度);问卷调查;肺吸虫病金标渗滤试剂盒(DIGFA-kit)检测血清抗体,抗体阳性者做肝功检查,并报告肺吸病肝损害2例。结果第二中间宿主以锯齿华溪蟹为主,流行区溪蟹的肺吸虫囊蚴携带率为92.36%(2 453/2 656);虫种鉴定为斯氏狸殖吸虫(Pagumogonimus skrjabini)。流行区居民食生蟹率23.08%(223/966),皮下游走性包块者4.45%(43/966)。流行区人群血清学DIGFA-kit检测肺吸虫抗体阳性率为4.84%(24/496);流行区人群有生食和半生食溪蟹的习惯,且感染与镇村、职业、年龄有关,差异均有统计学意义(P均<0.05)。血清肺吸虫抗体阳性者肝功结果显示γ球蛋白升高,白球蛋白比例倒置,ALT和AST轻度升高。结论合江县及毗邻流行区肺吸虫病的隐性感染依然存在;肺吸虫病对当地居民尤其是中小学生存在着很大的危害;应加强肺吸虫病防治知识的宣传和教育,制定相应的防制措施,阻断该病在该地区的流行。Objective To survey epidemic situation, clinical manifestation of paragonimiasis skrjabini in southern Sichuan region. Method Freshwater crabs were dissected and the rate of metacercaria infection （ degree ） were calcuLated. Quesuonnaire survey, DIGFA-kit to detect serum antibody were made. Two cases of liver damage by paragonimiasis were also reported. Result The second intermediate host was Sinopotamon denticulatum. The infection rate of freshwater crab infected by metacercaria was 92. 36% （2 453/2 656）. The species was identified as Pagumogonimus skrjabini. The rate of eating raw crab in residents was 23.08% （223/966）. The most remarkable manifestations were migratory subcutaneous nodules （ 4.45% , 43/966 ）.The positive rate of antibody of paragonimiasis detected by DIGFA-kit was 4. 84% （24/496）. Conclusion There are paragonimiasis in southern Sichuan. To control paragonimiasis in southern Sichuan region, comprehensive control measures and health education should be strengthened.

关 键 词：肺吸虫病 流行病学 临床表现 血清学诊断 

分 类 号：R532.22[医药卫生—内科学]