尿苷肽类抗生素sansanmycin E的分离、纯化和结构鉴定  

Isolation,purification and structure determination of uridylpeptide antibiotic sansanmycin E

作　　者：解云英[1] 许鸿章[1] 俞莹[1] 陈汝贤[1] 

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《中国抗生素杂志》2009年第6期326-328,共3页Chinese Journal of Antibiotics

摘　　要：目的从Streptomyces sp SS产生的尿苷肽类抗生素sansanmycins复合物中分离、提取和纯化小组分的尿苷肽类化合物,并进行结构鉴定。方法利用大孔树脂吸附、反相制备HPLC等方法进行分离纯化。利用光谱分析,进行结构解析。结果分离到一个尿苷肽类化合物sansanmycin E。结论经鉴定sansanmycin E为新结构化合物。Objective To isolate and purify the minor components from sansanmycins produced by Streptomyces sp SS and determine their structures. Method Sansanmycin E was isolated and purified by means of various chromatographies, such as macroporous adsorptive resins, reverse-phase preparative HPLC, etc. Its structure was elucidated by spectroscopic analyses. Result A uridyljpeptide antibiotic sansanmyein E was obtained. Conclusion Sansanmyein E was identified as a novel compound.

关 键 词：Sansanmycin E 尿苷肽类 Sansanmycins 

分 类 号：R978.19[医药卫生—药品]