加晶种控制头孢曲松钠溶析结晶产品粒度分布的研究  

Studies on the control of crystal size distribution of ceftriaxone sodium in dilution crystallization by seeding

作　　者：王海蓉[1] 张春桃[1] 王永莉[2] 

机构地区：[1]武汉科技大学化学工程与技术学院湖北省煤转化与新型炭材料重点实验室,武汉430081 [2]天津大学化工学院,天津300072

出　　处：《中国抗生素杂志》2009年第6期337-340,共4页Chinese Journal of Antibiotics

摘　　要：实验研究了晶种对头孢曲松钠溶析结晶过程产品粒度和粒度分布的影响。实验结果表明加晶种控制头孢曲松钠溶析结晶过程有利于得到平均粒度大、单分散性CSD的产品;晶种的加入量存在最优值;低的溶析剂浓度和慢的流加速率有利于获得较好的产品粒度和CSD,养晶时间宜控制在20min。Experimental studies were carried out to determine the effects of seeding on the product size and crystal size distribution （CSD） in the dilution crystallization of ceftriaxone sodium. The results indicated that seeding helped to produce ceftriaxone sodium with a large average size and a uni-modal CSD, so did the low concentration and slowly adding rate of anti-solvent; a critical seed loading in theory existed and the time of the seeds cultivation process could be controlled within 20 min.

关 键 词：头孢曲松钠 溶析结晶 晶种 粒度分布 

分 类 号：R978.11[医药卫生—药品]