无溶剂研磨合成6-氨基-8-芳基-2-甲基-5,7,7(1H)-三腈基-2,3,8,8a-四氢异喹啉衍生物  

Synthesis of 6-Amino-8-aryl-2-methyl-5,7,7(1H)-tricarbonitrile-2,3,8,8a-tetrahydroisoquinoline Derivatives under Solvent-Free Conditions Using a Ginding Method

作　　者：荣良策[1,2] 韩红霞[1] 姜虹[2] 庄启亚[1] 王苏惠[1] 屠树江[1,2] 

机构地区：[1]徐州师范大学化学化工学院,徐州221116 [2]江苏省药用植物生物技术重点实验室,徐州221116

出　　处：《有机化学》2009年第6期962-965,共4页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基础研究基金(No.08KJB150017);徐州师范大学培育基金(No.07PYL06)资助项目

摘　　要：NaOH存在下,无溶剂室温研磨芳醛、丙二腈、N-甲基哌啶-4-酮,方便地合成了一系列6-氨基-8-芳基-2-甲基-5,7,7(1H)-三腈基-2,3,8,8a-四氢异喹啉衍生物,该反应产率高,操作简单.所有产物的结构均经IR,1H NMR,元素分析进行了表征,并采用X-ray晶体衍射分析进一步确定了产物4d的结构.A series of 6-amino-8-aryl-2-methyl-5,7,7（1H）-tricarbonitrile-2,3,8,8α-tetrahydroisoquinoline derivatives were synthesized from aromatic aldehydes, malononitrile and N-methylpiperidin-4-one in the presence of sodium hydroxide under a solvent-free condition. The advantages of this procedure were simple protocol and high yields. The structures of products were determined by IR, ^1H NMR spectra, elemental analysis, and 4d was additionally confirmed by X-ray diffraction analysis.

关 键 词：芳醛 丙二腈 N-甲基哌啶-4-酮 无溶剂 研磨 

分 类 号：TQ25[化学工程—有机化工]