三组分一锅法合成3-(2-喹啉基)薁甲酸甲酯衍生物  

Three Component One-Pot Synthesis of Methyl 3-(2-Quinolyl)azulene-1-carboxylates

作　　者：孙曙光[1] 谷峥[1] 王道林[1] 韩珊[1] 黄孝东[1] 

机构地区：[1]渤海大学化学化工学院辽宁省应用化学重点实验室,锦州121003

出　　处：《有机化学》2009年第6期979-984,共6页Chinese Journal of Organic Chemistry

摘　　要：在质子酸作用下,以1-甲酰基薁-3-甲酸甲酯、芳香胺和脂肪醛为原料,三组分一锅法合成了一系列3-(2-喹啉基)薁甲酸甲酯衍生物.该反应收率良好、操作简单、条件温和.产物的结构通过红外光谱、核磁共振谱和元素分析证实,同时给出了该反应可能的反应机理.Methyl 3-（2-quinolyl）azulene-1-carboxylate derivatives were synthesized by three component one-pot condensation of methyl 1-formoylazulene-3-carboxylate, aromatic amines and alkylaldehydes under mild conditions. This method provides several advantages such as good yield and simple work-up procedure. All the products were fully characterized by ^1H NMR, IR spectra and elemental analysis.

关 键 词：薁 1-甲酰基薁 3-(2-喹啉基)薁 合成 

分 类 号：O626[理学—有机化学]