XIAP在年龄相关性听力减退C57BL/6J小鼠初级听皮质的表达  

Expression of X-linked inhibitor of apoptosis protein in primary auditory cortex in C57BL/6J mice with age related hearing loss

作　　者：李洪波[1] 陈继川[1] 姬长友[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所耳鼻咽喉-头颈外科,重庆400038

出　　处：《中华耳科学杂志》2009年第1期85-88,共4页Chinese Journal of Otology

基　　金：国家自然科学基金资助项目(项目编号:30872861)

摘　　要：目的探讨幼年和10月龄C57BL/6J小鼠听力及初级听皮质(AⅠ)中凋亡抑制蛋白XIAP的年龄相关变化。方法检测两组C57BL/6J小鼠听性脑干反应(ABR);免疫组织化学法染色检测两组C57BL/6J初级听皮质神经元凋亡抑制蛋白XIAP的表达情况。结果与幼年C57BL/6J小鼠相比,10月龄C57BL/6J的ABR反应阈值更高,凋亡抑制蛋白XIAP的表达显著减少。结论随年龄增长C57BL/6J小鼠的听力减退,同时C57BL/6J小鼠大脑初级听皮质凋亡抑制蛋白表达减少,XIAP的表达水平可能与C57BL/6J小鼠听力减退有关。Objective To study age-related changes in expression of X-linked inhibitor of apoptosis protein （XIAP） in the primary auditory cortex in C57BL/6J mice. Methods XIAP expression in the primary autiditory cortex （A I ） was measured using immunohistochemical methods and compared between a group of 15 1-2 month-old （5-20g） and a group of 15 10-12 month-old （50-60g） C57BL/6J mice. Results Expression of XIAP in A I showed significant decline in old mice compared to young mice. Conclusion The results provide direct morphological evidence indicating reduced XIAP presence in old C57BL/6J mice which may be a mechanism for age-related auditory function decline.

关 键 词：XIAP 初级听皮质 凋亡 听力减退 年龄 

分 类 号：R322.811[医药卫生—人体解剖和组织胚胎学] R764.436[医药卫生—基础医学]