白细胞介素8与肿瘤坏死因子α在宫颈炎症发病中的作用及其临床意义  

Pathogenesis and clinical significance of interleukin-8 and tumor necrosis factor-α in cervicitis

作　　者：宁玉梅[1] 王寅[2] 吕玲[1] 李瑞兰[1] 刘春娟[1] 江延姣[1] 祝秀芝[1] 

机构地区：[1]浙江中医药大学附属第一医院妇产科,杭州310005 [2]浙江中医药大学附属第一医院检验科,杭州310005

出　　处：《中华医学杂志》2009年第24期1684-1686,共3页National Medical Journal of China

基　　金：浙江省医药卫生科学研究基金（2007A150）

摘　　要：目的研究宫颈炎症患者阴道局部免疫状态与疾病发生的关系。方法应用酶联免疫吸附试验（ELISA）检测60例解脲支原体（UU）宫颈炎（UU组）、60例人型支原体（MH）宫颈炎（MH组）、60例沙眼衣原体（CT）宫颈炎（CT组）、30例淋病奈瑟菌（NG）宫颈炎（NG组）、60例宫颈糜烂患者（EC组）及与上述疾病相同例数的对照组（正常妇女）阴道灌洗液中自细胞介素（IL）-8和肿瘤坏死因子（TNF）-α的水平。结果（1）阴道灌洗液中IL-8水平：MH组为（371±34）ng／L、CT组为（369±31）ng／L、NG组为（339±36）ng／L，3组的同期对照组分别为（341±32）ng／L、（338±33）ng／L、（316±34）ng／L，两两比较差异均有统计学意义（均P〈0．01）；UU组、EC组与同期对照组比较，差异均无统计学意义（均P〉0．05）。（2）阴道灌洗液中TNF-α水平：除EC组外，其余各组均显著高于同期对照组，两两比较差异均有统计学意义（均P〈0．01）。结论在各种宫颈炎症的发病机制中，阴道局部免疫机制都发挥了重要作用；IL-8在MH、CT、NG引起的子宫颈特殊炎症的发病中可能具有更重要的作用。Objective To investigate the relationship between local immune status of vagina and the occurrence of disease in patients with cervicitis. Methods ELISA were used to detect the level of interleukin（IL）-8 and tumor necrosis factor（TNF）-α in vaginal douche of patients with cervieitis due to ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis, neisseria gonorrhoeae and cervical erosion. Results Compared with the control group, the level of IL-8 in vaginal douche of patients with mycoplasma hominis cervicitis, chlamydia trachomatis cervicitis and neisseria gonorrhoeae cervicitis was significantly higher and there was significant difference ng/L： 371 ± 34, 369 ± 31, 339 ± 36, vs 341 ± 32, 338 ± 33, 316 ± 24, （ all P 〈 0. 01 ）. Comparing the level of IL-8 in vaginal douche of patients with ureaplasma urealyticum cervicitis and cervical erosion with that of control group, there was no statistical difference（all P 〉0. 05）. The level of TNF-α in vaginal douche of each group was remarkably higher than that of control group except for patients with cervical erosion. And statistically significant difference was found between them （ all P 〈 0. 01 ）. Conclusion With regards to the pathogenesis of cervicitis, local immune mechanism of vagina plays an important role in the occurrence of cervicitis. The role of IL-8 in pathogenesis of mycoplasma hominis cervicitis, chlamydia trachomatis cervicitis and neisseria gonorrhoeae cervicitis is likely to be more important.

关 键 词：宫颈炎 白细胞介素8 肿瘤坏死因子Α 

分 类 号：R686[医药卫生—骨科学]