黄芪甙Ⅳ对豚鼠心电图及心室肌动作电位的影响  

Effects of astragalosideⅣon electrocardiogram and action potential of ventricular myocytes in guinea pigs

在线阅读下载全文

作  者:周云[1] 王俊杰[2] 赵伟[1] 张川 张卫东[3] 

机构地区:[1]上海交通大学基础医学院生理学教研室,上海200025 [2]济宁医学院生理学教研室,济宁276826 [3]第二军医大学药学院植物化学教研室,上海200433

出  处:《上海交通大学学报(医学版)》2009年第6期677-680,共4页Journal of Shanghai Jiao tong University:Medical Science

基  金:上海交通大学医学院和第二军医大学联合课题(04HX21006)~~

摘  要:目的观察黄芪甙Ⅳ对豚鼠心电图(ECG)及心室肌动作电位的影响。方法分别在麻醉豚鼠和Langendoff心脏灌流模型上记录体表ECG和离体心脏ECG,采用细胞内微电极技术记录豚鼠右心室乳头肌的动作电位。结果黄芪甙Ⅳ能延长豚鼠体表ECG和离体心脏ECG的RR间期,这一效应具有剂量依赖性。黄芪甙Ⅳ还能缩短动作电位的时程(APD),但对静息电位、动作电位幅度和最大去极速度没有明显影响。结论黄芪甙Ⅳ具有负性变时作用,能缩短心肌细胞APD,其作用机制可能与慢钙通道有关。Objective To observe the effects of astragaloside Ⅳ on electrocardiogram (ECG) and action potential of ventricular myocytes in guinea pigs. Methods ECG was recorded in vivo and ex vivo by using conventional ECG recording method from anesthetic guinea pigs and Langendoff perfusion model of hearts. Action potentials were recorded from isolated papillary muscles of right ventricles of guinea pigs by using microelectrode techniques. Results RR interval was prolonged by Astragaloside Ⅳ in a dose-dependent manner both in vivo and ex vivo. Astragaloside Ⅳ shortened action potential duration (APD), while had no effects on resting potential, action potential amplitude and maximal rate of depolarization. Conclusion Astragaloside Ⅳ exerts a negative chronotropic effect on heart and shortens APD of cardiac myocytes, which may be involved with calcium channels.

关 键 词:黄芪甙Ⅳ 心电图 心率 动作电位 钙通道 

分 类 号:R285[医药卫生—中药学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象