硬骨素在骨生成中的作用  

The effect of sclerostin on osteogenesis

作　　者：赵凤仪[1] 王莉[1] 

机构地区：[1]天津市天津医院

出　　处：《中国骨质疏松杂志》2009年第6期460-462,472,共4页Chinese Journal of Osteoporosis

摘　　要：硬骨素（sclerostin,SO）是硬化性骨化病（sclerosteosis,SOST）基因表达的一种蛋白产物。近年来,研究发现SO在骨生成发生机制方面具有重要的作用。研究发现在胚胎发生期间矿化骨中存在SOSTmRNA表达,在出生之后,骨细胞中SO蛋白和SOST mRNA表达均被严格地限制。在成骨细胞培养的矿化阶段,SOST mRNA表达水平有不同变化,其表达水平的差别与骨小梁的缺乏、存在及大小相关。还发现SOST mRNA表达与骨重建,细胞凋亡和细胞更新是紧密连锁的。The sclerostin（SO） is a kind of protein of the sclerosteosis（SOST） gene expression. In recent years, the research discovers that the SO has important function in the mechanism of osteogenesis. There are SOST mRNA expression in mineralized bone among embryonic period, and after born the SO protein product of bone cell and the SOST mRNA expressions are all limited strictly. The mineralized phase in the osteoblastic culture, the SOST mRNA expression level is variant, the difference of its expresses the level is related to deficiency of bone trabecula, size and its existence. And the SOST mRNA expression is closely linked to the bone remodel, the apoptosis and renewals.

关 键 词：硬骨素 硬化性骨化病 骨生成 基因表达 

分 类 号：R336[医药卫生—人体生理学]