慢性乙肝患者血清ACTA水平及临床评价  

The Serum ACTA Levels in Patients with Chronic Hepatitis B(CHB) and its Clinical Evaluation

作　　者：孔祥民[1] 刘忠艳[1] 傅春彬[1] 杨清[2] 

机构地区：[1]吉化公司总医院,吉林132000 [2]吉林大学第一医院输血科

出　　处：《临床消化病杂志》2009年第3期164-165,共2页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨激活素A(activin A,ACTA)在估价慢性乙型病毒性肝炎程度中的作用。方法采用酶联免疫(ELISA)法测定118例患者血清ACTA含量。采用放射免疫(RIA)法测定118例患者血清透明质酸(HA)、IV型胶原(CIV)、层黏连蛋白(LN)水平。结果118例慢性乙肝轻、中、重度及肝硬化患者血清ACTA、HA、CIV、LN均高于对照组,以上指标水平按轻、中、重度及肝硬化次序递增,并以肝硬化组为最高。除轻、中度级LN无显著差异外,其他各组间差异显著(P<0.01)。ACTA与HA、CIV、LN水平呈明显正相关(r=0.6188,P<0.01;r=0.5741,P<0.01;r=0.3336,P<0.05)。结论ACTA能较好地反映慢性肝病纤维化的进展程度,可作为临床评估慢性肝病病变程度和疗效的良好指标,亦可作为肝纤维化的诊断指标。Objective To observe the role of ACTA in patients with CHB. Methods The activin A （ACTA） cotents in 118 pstients with CHB were measured with ELISA,and the levels of HA,CIV and LN were measured with RIA. Results The levels of ACTA, HA, CIV and LN in mild, moderate, and severe patients with CHB and patients with cirrhosis were higher than those in the control group and increased stedly, reaching highest in patients with cirrhosis. The difference among the levels of LN in mild moderate group and control group were all not significant. The levels of the other factors were significantly different be- tween the rest groups（ P 〈0. 01 ）. The levels of ACTA,HA,CIV and LN was positively correlated. （ r = 0. 6188, P 〈 0.01; r = 0. 5741, P 〈 0.01 ; r = 0. 3336, P 〈 0. 05 ）. Conclusion The progression of chronic hepatic fibrosis was well reflected by the levels of ACTA. The levels of ACTA can also be a factor for clinical diagnosis of hepatic fibrosis and a ideal indicator for the evaluation degree in chronic liver disease.

关 键 词：肝纤维化 肝硬化 激活素A 

分 类 号：R512.62[医药卫生—内科学] R446.6[医药卫生—临床医学]