Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage  

作　　者：陈剑雄[1,2] 陈维洲[1,2] 黄红林 陈临溪 谢志忠 朱炳阳 

机构地区：[1]衡阳医学院药理教研室 [2]中国科学院上海药物研究所

出　　处：《中国药理学报》1998年第4期356-362,共7页Acta Pharmacologica Sinica

摘　　要：ＰｒｏｔｅｃｔｉｖｅｅｆｅｃｔｓｏｆＧｉｎｋｇｏｂｉｌｏｂａｅｘｔｒａｃｔａｇａｉｎｓｔｌｙｓｏｐｈｏｓｐｈａｔｉｄｙｌｃｈｏｌｉｎｅｉｎｄｕｃｅｄｖａｓｃｕｌａｒｅｎｄｏｔｈｅｌｉａｌｃｅｌｄａｍａｇｅＣＨＥＮＪｉａｎＸｉｏｎｇ，ＣＨＥＮＷｅｉ...AIM: To study the protective effects of Ginkgo biloba extract ( Gb E) against endothelial cell damage induced by lysophos-phatidyl-choline (LPC). METHODS: The vasorelaxation response to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aorta. Lipid peroxidation products were determined by measuring thiobarbituric acid reactive substance. RESULTS: Gb E attenuated the inhibition of vasorelaxation response to ACh and prevented the LPC induced increase of malondialdehyde (MDA) content both in thoracic aortae. Gb E prevented the leakage of LDH and the increase of MDA content in cultured endothelial cells in a concentration dependent manner. Gb E also markedly increased epoprostenol level in cultured endothelial cells treated with LPC. CONCLUSION: Gb E protected endothelial cells against LPC induced damage due to reduction in lipid peroxidation and facilitation of synthesis and/or release of epoprostenol.

关 键 词：银杏 溶血磷酯酰 胆碱 血管内皮 

分 类 号：R285.5[医药卫生—中药学]