可降解镁合金表面载药涂层的制备和性能  

Preparation and properties of drug-loaded coating on biodegradable magnesium alloy

作　　者：李绮[1] 汤岩[1,2] 谭丽丽[2] 颜廷亭[2] 张炳春[2] 杨柯[2] 

机构地区：[1]辽宁大学化学学院,沈阳110036 [2]中国科学院金属研究所,沈阳110016

出　　处：《材料研究学报》2009年第3期300-304,共5页Chinese Journal of Materials Research

基　　金：辽宁省教委自然科学基金No.2008222;中国科学院知识创新工程重要方向项目No.KGCX2-YW-207;中科院金属研究所青年人才领域前沿专项No.O7A7721171资助项目~~

摘　　要：在可降解AZ31B镁合金心血管支架表面成功制备了携带雷帕霉素的聚乳酸-聚三亚甲基碳酸酯(PLA-PTMC)共聚物涂层,评价了涂层的表面形貌、降解性能、血液相容性和药物释放性能。结果表明,PLA-PTMC共聚物作为载药涂层具有良好的柔韧性,表面均匀、光滑,降解周期超过1个月,血液相容性良好。涂层具有缓释雷帕霉素的功能,释药周期超过1个月,可在内膜增生期内有效抑制支架植入后再狭窄的发生,满足冠脉支架表面载药层的使用要求。The sirolimus-releasing PLA-PTMC coating was successfully prepared on the biodegrad- able AZ31B magnesium alloy coronary stents. The surface morphology, degradability, biocompatibility and drug release characteristic of the coating were also evaluated. The results indicated that PLA-PTMC used as the drug elution coating showed good flexibility with smooth and uniform surface, the degradation period was over one month, and the biocompatibility was excellent. The drug-loaded coating had releasing function of sirolimus and the releasing time was more than one month, which could effectively inhibit the restenosis during the period of intima hypertrophy. The sirolimus-releasing PLA-PTMC coating showed potential to be used as a new type of coronary stent coating.

关 键 词：有机高分子材料 药物洗脱支架 载药涂层 聚乳酸-聚三亚甲基碳酸酯共聚物 

分 类 号：TB324[一般工业技术—材料科学与工程]