钙通道拮抗剂增强大鼠曲马多镇痛  

AUGMENTATION OF THE ANTINOCICEPTIVE EFFECT OF TRAMADOL BY VERAPAMIL IN THE RAT

作　　者：胡兴云[1] 刘颖涛[1] 

机构地区：[1]湖北医科大学附属一医院

出　　处：《中国疼痛医学杂志》1998年第2期98-101,共4页Chinese Journal of Pain Medicine

摘　　要：目的：本实验旨在观察钙通道拮抗剂与曲马多联合外周应用对大鼠的镇痛效应。方法：痛阈测定选用热板法。腹腔注射不同剂量的维拉帕米（５、１０、２０ｍｇｋｇ）、曲马多（１０、２０、４０ｍｇｋｇ）或小剂量维拉帕米（５ｍｇｋｇ）和不同剂量曲马多（１０、２０、４０ｍｇｋｇ）联合注射。注药３０ｍｉｎ后测定痛阈。结果：曲马多单独应用时，镇痛效应确切，在所试剂量范围内与剂量正相关。维拉帕米单用时，无论剂量大小均无镇痛作用，但小剂量（５ｍｇ／ｋｇ）与不同剂量曲马多联用，可显著增强曲马多的镇痛效应。预注受体阻断剂的试验表明：钙通道拮抗剂增强曲马多镇痛的机制，与阿片受体有关。结论：钙通道拮抗剂可增强曲马多的镇痛作用，此联合用药方法简单、方便、危险性小，有在临床推广应用的前景。This study was designed to investigate the effects of calcium channel blocker on the antinociception of tramadol when the two drugs were coadministrated intraperitoneally in rats. Hot Plate were used to assess nociceptive sensitivity. Tramadol(10、20、40mgkg),verapamil(5、10、20mgkg) or verapamil(5mgkg)and tramadol(10、20、40mgkg) were injected intraperitoneally. Result: Intraperitoneal administration of tramadol induced a dose dependent antinociception. In contrast, i.p. injection of verapamil did not show any analgesia at the explored doses. A low dose of verapamil(5mgkg), however, could enhance the effect of tramadol, which could be abolished partly by pretreatment with naloxone. Conclusion:Calcium channel blocker could enhance the effect of tramadol.This combination has better prospect of clinical application for its samplicity,safety and convenience.

关 键 词：钙通道拮抗剂 维拉帕米 曲马多 镇痛 联合用药 

分 类 号：R441.1[医药卫生—诊断学]