利奈唑胺抗结核临床疗效  

Effects of linezolid in the treatment of patients with pulmonary tuberculosis

作　　者：赵立[1] 冯学威[1] 颜恒毅[1] 刘宏博[1] 

机构地区：[1]中国医科大学附属盛京医院呼吸内科,沈阳110004

出　　处：《中国临床药理学杂志》2009年第3期260-263,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察利奈唑胺(噁唑烷酮类抗菌药)对肺结核的疗效。方法3例利奈唑胺治疗肺结核临床疗效的病例,并附系统性相关文献复习。结果1例确诊和2例临床诊断肺结核患者,在接受利奈唑胺600 mg每日2次静脉滴注的单药治疗后,均在短期内(2天)迅速缓解高热、咳嗽、咳痰和周身不适等临床症状;1例患者用药2周后,肺部阴影明显吸收。国外采用利奈唑胺治疗肺结核多为联合用药,且患者为多重耐药的结核菌感染,最长疗程达28个月。已检索到的报告病例,经利奈唑胺治疗后,痰菌全部阴转。结论利奈唑胺具有抗结核作用,单药使用即可改善症状。Objective To investigate the efficacy of linezolid against pulmonary tuberculosis infection. Methods Case-series report and systematic review of linezolid for the treatment of patients with pulmonary tuberculosis. Results One confirmed and 2 suspected patients with pulmonary tuberculosis were treated by single use of linezolid, 600 mg iv drip bid. The clinical symptoms, including high fever, cough, sputum etc, were all relieved in 2 days. The CT scan of one of cases showed the shadow in the left lung obviously absorbed after 2 weeks treatment. Majority of previous reported cases were infected by multidrug-resistant tuberculosis and treated with linezolid-containing regimen. Longest course of one case was 28 months. The cultures of all reported cases converted to negative after linezolid therapy. Conclusion Linezolid has the efficacy against tuberculosis. The clinical symptoms could improve by single use of linezolid.

关 键 词：利奈唑胺 肺结核 

分 类 号：R521[医药卫生—内科学] R978.3[医药卫生—临床医学]