老年2型糖尿病患者胰岛素抵抗与脂联素、瘦素关系的探讨  

Relationship between insulin resistance and adiponectin,leptin in aged type 2 diabetes patients

作　　者：陈士华 周海鸥[2] 花扣珍[2] 蒋锦琴[2] 

机构地区：[1]浙江省平湖第一人民医院,浙江平湖314200 [2]浙江医学高等专科学校,杭州310053

出　　处：《中国卫生检验杂志》2009年第6期1363-1364,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:通过对老年2型糖尿病患者血清脂联素、瘦素水平检测及二者之间的比值分析,探讨老年2型糖尿病胰岛素抵抗发生的机理,为临床诊断治疗提供依据。方法:用酶联免疫分析和放射免疫分析对249例老年2型糖尿病和90例正常对照者及216例老年2型糖尿病经一年治疗前后脂联素、瘦素水平进行检测。结果:老年2型糖尿病患者脂联素水平明显低于正常对照组(P<0.01);瘦素水平2型糖尿病均高于正常对照组(P<0.01);216例老年2型糖尿病治疗前后比较,脂联素、瘦素及二者比值差异有显著(P<0.01),脂联素与瘦素比较呈负相关。结论:老年2型糖尿病胰岛素抵抗的发生与脂联素、瘦素密切相关,二者的比值变化对糖尿病分型具有重要意义。Objective： To nvestigate the relationship between development of insulin resistance and the change of adioponectin/ leptin ratio in aged type 2 diabetes patients, and explore the mechanism of insulin resistance for providing a basis for clinical diagnosis and treatment. Methods： Serum adiponectin and leptin levels were measured with ELISA and RIA in 249 aged patients with type 2 diabetes and 90 controls. Besides, the levels were measured in another 216 aged type2 diabetes patients both before and after one - year treatment. Results ： The serum levels of adiponectin in aged type 2 diabetes patients were significantly lower than those in controls （P 〈0. 01 ）. The serum levels of leptin in the aged patients with type 2 diabetes were significantly higher than those in controls （P 〈0.01 ）. In the 216 aged type 2 diabetes patients undergoing one year treatment, the adiponectin and leptin levels and the adiponectin/leptin ratio showed significant difference（ P 〈 0. 01 ）. Adiponectin level was inversely correlation with leptin level. Conclusion：The mechanism of insulin resistance is closely correlated with levels of adiponectin and leptin in aged type 2 diabetes patients. The change of adiponectin/leptin ratio is important for sub - type of diabetes.

关 键 词：2型糖尿病 胰岛素抵抗 瘦素 脂联素 放射免疫分析 

分 类 号：R587.1[医药卫生—内分泌]