HIV感染母亲分娩婴幼儿的体格生长发育状况研究  

The growth and development of children borne by HIV-infected mothers

作　　者：方利文[1] 崔立华[2] 王前[1] 王临虹[1] 孙定勇[3] 张伟[4] 张燕[5] 黄月华[6] 

机构地区：[1]中国疾病预防控制中心妇幼保健中心,北京100050 [2]华北煤炭医学院预防医学系河北省煤矿卫生与安全重点实验室,唐山063000 [3]河南省疾病预防控制中心性病艾滋病防治研究所,郑州450003 [4]新疆维吾尔自治区疾病预防控制中心妇幼保健中心,乌鲁木齐830002 [5]云南省妇幼保健院,昆明650051 [6]广西壮族自治区妇幼保健院,南宁530003

出　　处：《中国艾滋病性病》2009年第3期222-226,共5页Chinese Journal of Aids & STD

基　　金：国家"十五"科技攻关课题资助(2004BA719A03)

摘　　要：目的了解艾滋病病毒(HIV)感染母亲分娩的婴幼儿的体格生长发育状况。方法对我国4个艾滋病高发省的7个县/区,HIV感染母亲分娩的活产婴幼儿,分别在出生时、3、6、9、12、15、18月龄进行随访调查及生长发育监测,分析18月龄存活婴幼儿的体格生长发育指标。结果2005-2008年,共调查18月龄存活婴幼儿154名,其中HIV感染婴幼儿22名,非感染婴幼儿132名。结果:(1)HIV感染婴幼儿在6-18月龄的身长、体重明显低于非HIV感染婴幼儿(P<0.05),年龄别头围的差别无统计学意义。(2)与世界卫生组织(WHO)儿童生长标准比较,非HIV感染婴幼儿中,男、女童6月龄前的年龄别体重与该标准无差别,6月龄后的年龄别体重高于该标准(P<0.05);年龄别体重Z值(WAZ)和身长别体重Z值(WHZ)在-0.1～1之间;男、女童12月龄内的年龄别身长与该标准的差别无统计学意义,15-18月龄身长低于该标准(P<0.05),年龄别身长Z值(HAZ)和年龄别头围Z值在-0.1～-1之间。(3)HIV感染男、女童各月龄的体重、头围与WHO标准的差别无统计学意义,15-18月龄身长低于该标准;随访期间WAZ在0.2～-0.6之间,3月龄内WAZ下降较快,之后处于低水平状态;HAZ在0.1～-1.7之间,呈下降趋势,在6-12月龄接近-1,15-18月龄低于-1。结论HIV感染母亲分娩的非HIV感染婴幼儿的体格生长不足,身长、头围发育较差,而HIV感染婴幼儿更为严重。Objective To compare the physical growth and development of HIV positive and negative infants borne by HIV-infected mothers. Method A follow--up study including growth surveillance was conducted for in- fants at birth, 3, 6, 9, 12, 15 and 18 months of age in 7 counties/districts of 4 provinces with high HIV prevalence from 2005--2008. An analysis was made to assess the growth and development indicators of 154 children at 18 months of age. Results From 2005 to 2008, there are 154 live newborns of 18-month to be selected in survey. Thereinto,22 of them were infected HIV and 132 of them do not take HIV. 1. The length and weight of the HIV in- fected infants at 6--18 months was lower than those free of HIV infection（p〈0.05）. The difference in age-related head circumference between the two groups had no statistical significance. 2. The age--related weight for infants free of HIV infection was within the WHO standard before 6 months of age, but higher than the WHO standard af- ter 6 months（p〈0.05）. Z values for age--related weight （WAZ） and height--related weight （WHZ） were between --0.1 and 1. Age-related height had no statistically significant difference with the WHO standard at one year for both boys and girls, but was lower than the standard at 15--18 months of age（p%0.05）; Z values for age--related height （HAZ） and age-related head circumference ranged from -- 0.1 to -- 1. 3. The weight and head circumference of the HIV-infected infants had no sta- tistically significant difference with the WHO standard at any age, but their length was lower than the WHO standard at 15- 18 months. Z values for age-related weight （WAZ） were between 0.2 and --0.6. WAZ declined quickly in children of 3 months , and then was at a low or stable level . HAZ went down from 0.1 to --1.7, which was close to --1 at 6--12 months, and lower than --1 at 15--18 months. Conclusion The physical growth and development of HIV negative infants borne by HIV-infected mothers was lower than the WHO standards, espe- ciall

关 键 词：艾滋病 儿童 生长发育 

分 类 号：R512.91[医药卫生—内科学]