铬对克山病病区粮致心肌损伤的保护机理探讨  

THE PROTECTIVE MECHANISM OF CHROMIUM ON MYOCARDIAL INJURY INDUCED BY CEREALS FROM KESHAN DISEASE ENDEMIC AREAS

作　　者：相有章[1] 边建朝[1] 杨晓霞[1] 宋术亮[1] 王林[1] 刘永平[1] 

机构地区：[1]山东省地方病防治研究所

出　　处：《营养学报》1998年第2期188-192,共5页Acta Nutrimenta Sinica

基　　金：国家自然科学基金

摘　　要：方法：采用克山病病区粮分别加Ｃｒ３＋、加Ｓｅ喂养大鼠，以荧光偏振法测定心肌细胞线粒体膜流动性，低温顺磁共振技术直接测定心、肝自由基含量，同时观察ＧＳＨ－Ｐｘ及ＳＯＤ活性变化。结果：在缺Ｓｅ状态下膜流动性降低，心、肝自由基水平升高，ＧＳＨ－Ｐｘ及ＳＯＤ活性降低，加Ｃｒ３＋或加Ｓｅ喂养的大鼠膜流动性明显改善，自由基水平显著降低，ＧＳＨ－Ｐｘ及ＳＯＤ活性亦有改善。结论：增强抗氧化功能可能是Ｃｒ３＋抗心肌损伤的重要机理之一。In order to explore the protective mechanism of Cr 3+ on myocardial injury in Se deficient condition,the rats fed with endemic areas grains were classed into 4 groups:endemic diet,endemic diet+Cr 3+ ,endemic diet+Se,endemic diet+Cr 3+ +Se.After 100 days feeding the rats were killed.Membrane lipid fluidity(FLU)of myocardial cells was measured with fluorescent polarization analysis.Free radicals of myocardium and liver were examined with low temperature ESR technique,as well as the activities of GSH Px and SOD were observed.The results showed that FLU was significantly increased,free radicals were markedly decreased and the activities of GSH Px and SOD in blood,myocardium and liver were obviously significantly reduced in Se deficient condition.While endemic diet supplemented with Cr 3+ ,Se or Cr 3+ +Se,FLU was significanfly improved,free radicals were markedly decreased and activities of GSH Px and SOD were increased.It was possible that improving antioxidation function is one of the mechanisms of Cr 3+ on myocardial injury.

关 键 词：铬 硒 膜流动性 克山病 心肌损伤 

分 类 号：R542.306[医药卫生—心血管疾病] R542.201[医药卫生—内科学]