丹参提取物(764-3)对不同类型肺动脉高压大鼠泡内动脉结构变型的影响  

Effects of an extract of salviae miltiorrhizae (764 3) on structural remodeling of intra acinar pulmonary artery in pulmonary hypertension due to chronic hypoxia and monocrotaline in rats

作　　者：柳志红[1,2] 程显声[1,2] 蔡如升 孙本韬 李群[1,2] 李亚辉 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院 [2]山西医学院

出　　处：《中华结核和呼吸杂志》1998年第6期358-360,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金

摘　　要：目的观察丹参提取物（７６４－３）对不同类型肺动脉高压大鼠肺腺泡内肌型（ＭＡ）、部分肌型（ＰＭＡ）和非肌型（ＮＭＡ）动脉百分比构成及ＭＡ中膜胶原含量的影响。方法将雄性Ｗｉｓｔａｒ大鼠随机分为１２组。缺氧大鼠置于５１ｋＰａ低压舱内２或４周；野百合碱组（ＭＣＴ）大鼠以ＭＣＴ６０ｍｇ／ｋｇ一次腹腔注射，观察４周。给药大鼠：７６４－３２０或４０ｍｇ／ｋｇ皮下注射，每日１次；β氨基丙腈（ＢＡＰＮ）１５０ｍｇ／ｋｇ腹腔内注射，每日２次。于每一观察终点，行血液动力学检查，计算ＭＡ、ＰＭＡ、ＮＭＡ比例及形态定量ＭＡ中膜胶原含量。结果缺氧２周时，ＭＡ明显增多，ＮＭＡ减少（Ｐ均＜０．００１），ＰＭＡ比例无明显变化；４周时，ＭＡ和ＰＭＡ进一步增多（后者与正常组比Ｐ＜０．０５），ＮＭＡ进一步减少，且ＭＡ中膜胶原含量明显增多（Ｐ＜０．００１）。ＭＣＴ大鼠上述改变重于缺氧大鼠。７６４－３及ＢＡＰＮ均能明显改善上述血管比例关系，减少中膜胶原堆积（Ｐ均＜０．００１），且ＢＡＰＮ抑制胶原堆积的作用强于７６４－３（Ｐ＜０．０５）。结论慢性缺氧及ＭＣＴ诱发的大鼠肺动脉高压进展过程中，均有泡内肌型肺动脉比例增多，中膜胶原过度堆积，非肌型动脉肌性化。?Objective To investigate the effects of an extract of salviae miltiorrhizae (764 3) on the percentage of intra acinar muscular artery (MA), partal MA(PMA) and nonmuscular MA(NMA) and collagen deposition in the media of MA in rats with hypoxia and MCT induced pulmonary hypertension. Method Wistar rats were divided into 12 groups. The hypobaric hypoxic 51 kPa (1 kPa=7.5 mmHg) and MCT (60 mg/kg intraperitoneal injection) rats were treated with 764 3 (20 mg/kg), β aminopropionitrile (BAPN, 150 mg/kg) and 764 3 (40 mg/kg), respectively. At each time point, the hemodynamic and morphological parameters were measured. Result After hypoxia for 2 weeks, the percentage of MA increased ( P <0.001), of NMA decreased ( P < 0.001) and of PMA no obvious change; and after 4 weeks, the above changes became to be more striking and the collagen content in the media of MA increased ( P <0.001). The MCT treated rats had more severe changes than the hypoxic rats. Both 764 3 and BAPN could inhibit the changes, decreased the collagen content and BAPN was more effective than 764 3( P <0.05). Conclusion 764 3 can partially inhibit collagen deposition in pulmonary arterioles attenuate hypoxia and MCT induced pulmonary hypertension, reduce the percentage of MA, and has a moderate influence on collagen deposition as compared with BAPN.

关 键 词：肺动脉高压 丹参提取物 泡内动脉 结构变型 

分 类 号：R543.2[医药卫生—心血管疾病]