9-羟基-9-呫吨羧酸甲酯和中间体的合成  

Synthesis of Methyl 9-Hydroxyl-9-xanthene Carboxyate and Intermediate

作　　者：孔博[1] 弓亚玲[1] 胡文祥[1] 

机构地区：[1]首都师范大学化学系,北京100048

出　　处：《化学通报》2009年第6期569-572,共4页Chemistry

基　　金：中国博士后科学基金项目(20070410564)资助

摘　　要：9-羟基-9-呫吨羧酸甲酯是合成呫吨类抗胆碱能药物的一种重要的中间体。本文以9-呫吨羧酸为原料,通过微波催化先合成了中间体9-呫吨羧酸甲酯,然后很简便地得到了9-羟基-9-呫吨羧酸甲酯。在中间体的合成中,利用正交设计,探讨了微波辐射时间、功率以及催化剂用量对反应的影响,实验结果表明微波辐射时间的影响最为显著。Methyl 9-hydroxyl-9-xanthene carboxyate which is an important intermediate of xanthene anticholiergic drugs was easily synthesized from methyl 9-xanthene carboxyate. Synthesis of methyl 9-xanthene carboxyate by microwave catalysis was studied through orthogonal design, the effect of time and power of microwave and amount of catalyst were investigated. It was found that the effect of time was notable.

关 键 词：9-羟基-9-咕吨羧酸甲酯 9-咕吨羧酸甲酯 微波催化 正交设计 

分 类 号：TQ25[化学工程—有机化工]