活体肝移植的策略、创新和结果  

STRATEGIES, INNOVATIONS, AND OUTCOMES IN LIVING DONOR LIVER TRANSPLANTATION

作　　者：陈肇隆 邹一平(译) 

机构地区：[1]长庚纪念医院高雄医学中心,中国台湾 [2]不详

出　　处：《中华肝胆外科杂志》2009年第6期402-403,共2页Chinese Journal of Hepatobiliary Surgery

摘　　要：目前活体肝移植手术成功率高，主要由于明知的供受体选择、仔细的术前计划、完美的术中麻醉和并发症的及时发现和处理。然而，在所报道的病例中，受体较高的1年生存率没有同样转化为较高的5年生存率，美国器官捐赠和移植网络（OPTN）报道活体肝移植的受体1年和5年生存率分别为81．79／6和69．7％，他们所反映的事实就需要笔者对这种手术的优势和问题的解决方法予以关注，包括因疾病的复发、肾功能不全、钙调神经磷酸酶抑制剂毒性作用、后期感染和晚期或亚临床排斥反应所导致的移植失败。Living donor liver transplantation （LDLT） is now per- formed with high rates of success due to judicious donor and recipient selection, careful preoperative planning, excellent anesthesia management, and prompt detection and treatment of complications. However, the high 1-year recipient surviv- al among reported series does not translate to a similariy high 5-year recipient survival. The 81. 7% 1-year and 69.7% 5 year graft survivals among LDLT recipients reported by the U.S. Organ Procurement and Transplant Network （OPTN） reflect the fact there are concerns that require preponderance and solutions. Among these concerns are graft failure from recurrent disease, renal dysfunction, calcineurin inhibitor toxicity, late infections, and late or sub-clinical rejections.

关 键 词：活体肝移植 5年生存率 亚临床排斥反应 手术成功率 磷酸酶抑制剂 受体选择 肾功能不全 术前计划 

分 类 号：R686[医药卫生—骨科学]