藏药小叶毛球莸中对映-贝壳杉烯型二萜类成分研究  

Two en-kaurene diterpenoids from Tibetan medicine Caryopteris toroetii

作　　者：确生[1] 赵玉英[2] 周勇[2] 张庆英[2] 

机构地区：[1]青海师范大学民族师范学院化学系,青海西宁810008 [2]北京大学药学院天然药物学系,北京100191

出　　处：《中国中药杂志》2009年第12期1523-1526,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(20872006)

摘　　要：目的:研究藏药小叶毛球莸的化学成分。方法:采用溶剂法和色谱法提取分离化学成分,并用波谱方法鉴定化学成分结构。结果:从藏药小叶毛球莸中分离得到2个对映-贝壳杉烯型二萜类化合物:冬凌草甲素(1)和nodosin(2),并首次报道了该两个化合物在甲醇(CD3OD)中的1H和13C-NMR数据。结论:对映-贝壳杉烯型二萜类化合物为首次从莸属植物中分离得到。Objective： To study the chemical constituents of Tibetan medicine Caryopteris toroetii. Method： The crude drug was extracted with 95% EtOH and isolated by repeated chromatographic methods. The structures of the isolated compounds were eluci- dated on the basis of spectral analysis. Result： Two en-kaurene diterpenoid compounds ： oridonin （ 1 ） and nodosin （2）, were obtained from C. toroetii and their ^1H and ^13C-NMR data in CD3OD were reported for the first time. Conclusion： The en-kaurene diterpenoid compounds were obtained from genus Caryopteris for the first time.

关 键 词：藏药 莸属 小叶毛球莸 对映-贝壳杉烯型二萜 冬凌草甲素 NODOSIN 

分 类 号：R29[医药卫生—民族医学]