纳米羟基磷灰石对两种药物的载药性能研究  

Preparation and Characterization of Nanohydroxyapatite as Carrier of Two Drugs

作　　者：陈庆榆[1] 朱融融[2] 张蕤[2] 田川[2] 孙晓宇[2] 汪世龙[2] 

机构地区：[1]安徽科技学院,蚌埠233100 [2]同济大学生命科学与技术学院,上海200092

出　　处：《复旦学报（自然科学版）》2009年第3期386-390,共5页Journal of Fudan University：Natural Science

基　　金：国家自然科学基金资助项目(50673078);国家"八六三"高技术研究发展计划重点资助项目(2007AA022004)

摘　　要：骨缺损常常伴随着炎症、肿瘤等情况,以各种骨修复材料为载体的药物缓释体系是一种新型的给药方式.以纳米羟基磷灰石(n-HA)为载药体系,用红外光谱和透射电镜表征了n-HA的结构,考察了其对抗生素阿莫西林和抗肿瘤药鬼臼毒素的不同吸附作用,并研究其对抗生素阿莫西林吸附量的影响.实验结果表明,n-HA的红外图谱及粒径与人体骨颇为接近,同时n-HA可以吸附有羟基的阿莫西林,并且吸附性能随着阿莫西林初始浓度的不同而不同,吸附速度快,4 h达到吸附平衡;但是对没有特征基团的鬼臼毒素,n-HA不能吸附.n-HA这种对有某些特征基团分子的特异性吸附作用,对载药骨材料的研究具有非常重要的指导意义.Bone defect is usually accompanied with inflammation and tumor. Control delivery system based on bone repair material is a new type of drug delivery methods, n-HA is prepared and evaluated as the drug delivery system for amoxicillin and podophyllotoxin. TEM and FTIR were used for the detection of the morphology of n-HA and the absorption ratio of amoxicillin and podophyllotoxin. The results showed that the IR spectrum of n-HA is similar to that of natural bone. It＇s also revealed that amoxicillin with -OH can be absorbed by n-HA, but hot podophyllotoxin without -OH. The intensity of absorption is different with different dose of amoxicillin, and the adsorption reaches equilibrium after 4 h. n-HA has special absorption effect on drugs with special group, which might highlight the research of bone materials for drug delivery system.

关 键 词：纳米羟基磷灰石 载药 阿莫西林 鬼臼毒素 生物相容性 

分 类 号：Q819[生物学—生物工程]