乙醇对家兔动脉零应力状态的影响  

A Study on the Zero-stress State of Rabbit Artery after Intragastric Administration of Ethanol

作　　者：张奎[1,2] 王献民[3] 王雷[1] 胡林[1] 廖志钢[1] 

机构地区：[1]四川大学基础医学与法医学院法医病理学教研室,成都610041 [2]遵义医学院,遵义563000 [3]四川大学华西二院心血管儿科,成都610041

出　　处：《生物医学工程学杂志》2009年第3期488-490,共3页Journal of Biomedical Engineering

基　　金：四川大学创新基金资助课题(2006y001)

摘　　要：探讨乙醇对家兔动脉零应力状态的影响。本试验通过灌胃的方法建立血液乙醇浓度梯度的家兔动物模型，测定各灌胃量组血液乙醇浓度。通过测量血管张开角的方法，测定不同灌酒量作用2h后家兔的胸主动脉、腹主动脉及脑基底动脉的零压力状态。结果表明，家兔灌酒后血液乙醇浓度持续增高；灌酒后1．5～2h，血液乙醇浓度达到峰值；灌酒后血液乙醇浓度与灌酒量存在正相关关系。各灌酒组胸主动脉、腹主动脉及脑基底动脉张开角均明显降低，且随灌酒量的增大，动脉张开角降低越明显，各组之间差异存在统计学意义（P〈0．05）。家兔胸主动脉、腹主动脉及脑基底动脉零应力状态与血液乙醇浓度大小存在正相关关系。To investigate the effect of ethanol on the zero-stress state of rabbit artery, a rabbit animal model of blood ethanol concentration gradient was established by intragastrie administration of ethanol （IGAE）. The blood ethanol concentration of each group was measured. The zero-stress state characterized by opening angle was observed by an image processing system. The results revealed that the blood ethanol concentration of each group increased after IGAE. The magnitude of the blood ethanol concentration came to the peak at 1.5-2h after IGAE. The opening angle decreased with the increase of the magnitude of blood ethanol concentration and the opening angle in each group. These findings suggest that the zero-stress state of the rabbit artery has close relationship with ethanol concentration.

关 键 词：乙醇 张开角 零应力状态 

分 类 号：R318.01[医药卫生—生物医学工程]