猪胆总管的生物力学特性与年龄的关系  

The Relationship Between Age and Biomechanical Properties in Porcine Common Bile Duct

作　　者：李文春[1] 唐杰[1] 张兴华[1] 余明华[1] 

机构地区：[1]郧阳医学院医用生物力学实验室,十堰442000

出　　处：《生物医学工程学杂志》2009年第3期530-533,共4页Journal of Biomedical Engineering

基　　金：湖北省教育厅科学技术研究项目资助(B20082410);郧阳医学院研究生启动项目资助(2005QDJ05)

摘　　要：本研究的目的是探讨猪胆总管的生物力学特性与年龄的关系。50例3～12月龄湖北白猪的胆总管，在软组织生物力学试验机上进行压力一直径实验，计算出弹性模量和顺应性。横断取材，冰冻切片，HE染色，用计算机图像分析系统测量其管径和壁厚。结果显示，各月龄组猪胆总管的顺应性均有差异（F=59．69，P=0．00）；猪胆总管的顺应性随月龄增加而增大，10月龄后又减小。7～10月龄猪胆总管的顺应性差异不大（P〉0．05）；而3～6月龄及11月和12月龄猪胆总管的顺应性明显小于7～10月龄（P〈0．01）。猪胆总管的弹性模量随月龄的变化与顺应性的变化相反。提示，猪胆总管的生物力学特性随年龄增加而发生变化，7～10月龄猪胆总管的顺应性较好；在猪到人异种肝移植时，选用7～10月龄猪的肝脏作为供体材料也许更匹配。The aim of this study was to detect the relationship between age and biomechanical properties in porcine common bile duct （CBD）. The CBDs of 50 Hubei white pigs aged 3-12 months were obtained. The experiment of pressure -diameter was conducted on the biomeehanical experiment stand for soft tissues, and then the elastic modulus and compliance were calculated. The materials were transversely extracted, refrigerated, and sliced up before HE staining. The diameter and wall thickness of the CBD were measured by a computer image analysis system. The results showed that there was statistically significant difference in regard to the compliance of the porcine CBDs of different months （F= 59.69, P=0. 00）. The compliance of the porcine CBD increased gradually with monthly age. However, after the pigs being aged 10 months, the compliance decreased gradually with monthly age. The compliance of the CBD of pigs aged 7-10 months was not significantly different （P〉0.05）, but the compliance of the CBDs of pigs＇ aged 3-6 months and 11-12 months was significantly lower than that of pigs aged 7-10 months （P〈0.01）. The changes in elastic modulus of porcine CBD with age were opposed to the changes in compliance. The results of the present study suggests that the in biomechanical properties of pigs＂ CBDs change with their ages, and the CBDs of pigs aged 7410 months have good compliance. Thus, for the pig-to-human liver xenotransplantation, the livers of pigs aged 7-10 months, being chosen as donators, may be more conducive to matching.

关 键 词：猪 年龄 胆总管 生物力学 

分 类 号：R318.01[医药卫生—生物医学工程]