氯硝柳胺乙醇胺盐降解规律研究Ⅰ光解液氯硝柳胺乙醇胺盐含量测定  

Studies on degradation mechanism of niclosamide ethanolamine salt Ⅰ Determination of niclosamide ethanolamine salt in photolysis solution

作　　者：戴建荣[1] 曹建平[2] 李洪军[1] 汪伟[1] 廖慨[2] 陶永辉[1] 梁幼生[1] 

机构地区：[1]江苏省血吸虫病防治研究所、卫生部寄生虫病预防与控制技术重点实验室、江苏省寄生虫分子生物学重点实验室、江苏省寄生虫病学重点学科,无锡214064 [2]厦门大学海洋与环境学院

出　　处：《中国血吸虫病防治杂志》2009年第3期205-208,211,共5页Chinese Journal of Schistosomiasis Control

基　　金：江苏省自然科学基金(BK200602)

摘　　要：目的了解氯硝柳胺乙醇胺盐(NES)在水体中的光解规律。方法实验室配置pH5的0.05μg/ml、pH7的0.5μg/ml和pH9的2.5μg/mlNES溶液,采用氙灯光源作为模拟日光照射,照射后0、0.5、1、2、4、8、16、24、48、72、96h采集光解液,高效液相色谱法测定光解液中NES含量,同时设无光照对照试验,计算其半衰期。结果在氙灯光光照条件下,NES快速降解,8h3种pH值的NES溶液下降率分别为83.4%、78.8%和41.3%,24h下降率分别为92.1%、88.5%和95.8%。NESpH5半衰期为8.98h,pH7为10.34h,pH9为9.16h;无光照条件下放置12d溶液浓度稳定。结论NES可在水中快速光解。Objective To understand the photolysis mechanism of niclosamide ethanolamine salt （NES） in water body. Methods NES was formulated into solutions of pH 5 （0.05 μg/ml）, 7 （0.5 μg/ml） and 9 （2.5 μg/ml）, respectively. The xenon gas lamp was used as the simulated sunlight. After 0, 0.5, 1,2, 4, 8, 16, 24, 48, 72, 96 h of the illumination, the photolysis solutions were collected to determine the amount of NES by using the high-performance liquid chromatography method （HPLC） , and the experiment without illumination was also set as the control. The half-life was calculated. Results Under the illumination of xenon gas lamp, the NES degraded rapidly. The degradation rates were 83.4%, 78.8% and 41.3%, respectively for 8 h, and 92.1%, 88.5% and 95.8% , respectively for 24 h. The half-life of NES was 8.98 h for pH 5, 10.34 h for pH 7, 9.16 h for pH 9. The solution could keep stable for 12 d without illumination. Conclusion Photolysis of NES can occur quickly in water.

关 键 词：氯硝柳胺乙醇胺盐 光解 高效液相色谱(HPLC) 半衰期 

分 类 号：R383.24[医药卫生—医学寄生虫学]