抗膜联蛋白A2抗体在抗磷脂综合征中的作用  

The role of anti-annexin A2 antibodies in antiphospholipid syndrome

作　　者：敖文[1] 郑辉[1] 陈晓微[1] 申艳[1] 杨程德[1] 

机构地区：[1]上海交通大学医学院附属仁济医院风湿病学科,200001

出　　处：《中华风湿病学杂志》2009年第6期364-367,共4页Chinese Journal of Rheumatology

基　　金：国家自然科学基金（30772009）;上海市教委重点学科建设项目（T0203）

摘　　要：目的研究抗膜联蛋白A2抗体在抗磷脂综合征（APS）、系统性红斑狼疮（SLE）的血栓，病态妊娠中的可能作用。方法先用分子克隆方法表达纯化出重组膜联蛋白A2，然后以重组膜联蛋白A2为抗原，采用酶联免疫吸附试验（ELISA）法分别检测了101例APS患者，41例SLE合并血栓患者，124例无血栓的SLE患者及120名健康人的血清中IgG型抗膜联蛋白A2抗体水平。结果APS组和SLE合并血栓组的1gG型抗膜联蛋白A2抗体阳性率分别为21．8％，26．8％，均显著高于单纯SLE组（6．5％）（P值均〈0．01）。IgG型抗膜联蛋白A2抗体与血栓，病态妊娠有关联（P〈0．01）。IgG型抗膜联蛋白A2抗体对血栓，病态妊娠诊断的敏感性、特异性、预测值分别为0．232、0．935、0．805。结论IgG型抗膜联蛋白A2抗体与APS和SLE患者的血栓／病态妊娠表现相关，将有助于一些潜在的APS患者的诊断。Objective This study has explored the role of antibody against annexin A2 in patients with antiphospholipid syndrome （APS） and systemic lupus erythematosus （SLE）. Methods Using purified recombinant annexin A2, IgG anti-annexin A2 antibody was measured by ELISA in 101 APS patients, 41 SLE patients with thrombosis, 124 SLE patients without thrombosis and 120 healthy controls. Results The positive rate of IgG anti-annexin A2 antibody in APS patients amt SLE patients with thrombosis was 21.8%, 26.8%, respectively, they were all significantly higher than in SLE patients without thrombosis （6.5%）. IgG anti- annexin A2 antibody was associated with thrombosis and/or pregnancy morbidity （P〈0.01）. Conclusion Anti-annexin A2 antibody is associated with thrombosis and/or pregnancy morbidity. It suggests that anti- annexin A2 antibody may be helpful in identifying in some potential APS.

关 键 词：膜联蛋白A2 抗体 抗磷脂 血栓形成 抗磷脂综合征 

分 类 号：R686[医药卫生—骨科学]