哺乳动物Hepcidin表达调控的研究进展  

Expression and Regulation of Hepcidin in Mammals

作　　者：慕玉[1] 王海静[1] 赵宝华[1] 

机构地区：[1]河北师范大学生命科学学院,石家庄050016

出　　处：《四川动物》2009年第4期633-635,共3页Sichuan Journal of Zoology

基　　金：河北省自然科学基金资助项目(No.C2007000263)

摘　　要：Hepcidin是由生物体肝脏表达的一种具有抵抗外界微生物侵害的小分子阳离子多肽,与干扰素、补体等组成了宿主的免疫防御系统。哺乳动物的Hepcidin表达调控受多种因素的影响。本文主要介绍了机体内铁水平、感染和炎症、贫血和缺氧以及运动对Hepcidin表达调控的影响。铁超负荷、脂多糖和病原体可诱导Hepcidin的表达,而贫血、缺氧和运动可下调其表达。本文还对Hepcidin的临床应用研究中存在的问题进行了初步讨论。Hepcidin is a small cationic peptide generated in the liver that functions against bacterial invasion, making up of the host＇s immune defense system with interferon and complement. The expression and regulation of hepcidin in mammals are affected by many factors. This paper characterized the impact of systemic iron homeostasis, inflammation, anemia, shortage of oxygen, and the organism＇s activity level on the expression and regulation of hepcidin. Iron overload, the injec- tion of lipopolysaccharides and pathogens up-regulate the expression of hepcidin, while anemia or shortage of oxygen down- regulates its transcription level. This paper also discussed some issues on the clinical application of hepcidin research.

关 键 词：HEPCIDIN 铁超负荷 表达调控 展望 

分 类 号：Q953[生物学—动物学]