尿激酶胸腔内注入后当次抽液治疗结核性包裹性胸腔积液  

Treatment of tuberculous pleural effusion by intrapleural cavity injection of urokinase

作　　者：陈小可[1] 周一平[1] 彭蕻琳[1] 李明[1] 刘慧[1] 刘念[1] 陈霞[1] 

机构地区：[1]广东医学院附属深圳福田人民医院呼吸科,广东深圳518033

出　　处：《中国热带医学》2009年第7期1317-1317,1353,共2页China Tropical Medicine

摘　　要：目的探讨尿激酶胸腔内注入治疗包裹性胸腔积液,注药后当次抽液的疗效。方法55例结核性网状粘连包裹性胸腔积液患者分为两组。治疗组28例在胸腔内注入尿激酶后10min内即抽液,对照组27例在胸腔内注入尿激酶2～3d后抽液。结果两组患者注药后首次抽液量、治疗后抽液总量无显著差异,但治疗组所需的注药次数、胸穿次数、胸水吸收时间显著少于对照组。治疗后B超测胸膜厚度两组无明显差异。结论胸腔内注入尿激酶后,短时间内(10min)即可达到很好的治疗胸膜粘连、包裹的作用,当次抽液较常规的注药2～3d后抽液有一定优势。Objective To investigate the effects of immediately drainage after intrapleural urokinase injection for treatment of loculated tuberculous pleural effusions. Methods There 55 patients with loculated tuberculous pleural effusion were divided into 2 groups, 28 patients in immediately drainage group （group 1 ） and 27 patients in delay drainage group （group 2）. The patients in beth groups were injected with urokinase 200 000 IU intrapleurally if there was no more fluid drained out. The drainage was carried out 10 minutes after use of urokinase in group 1, while in group 2, the following drainage was 2-3days after infection of urokinaser. Results There was no significant difference in thefluid volume of first drainage and total drainage fluid volume after the injection of urokinase between the groups Thickness of pleura after treatment in groupsl was 1.22±0.21mm , and it was 1.16±0.19 nun in group2 （P〉0.05）. The mean number of injection and thoraeocentesis was less in group I（P〈0.01 ）. Conclusion Intrapleural urokinase injection is effective soon after injection.

关 键 词：尿激酶 结核 胸膜炎 

分 类 号：R521.7[医药卫生—内科学]