单唾液酸四己糖神经节苷脂钠联用醒脑静注射液治疗急性重型颅脑外伤的疗效观察  

作　　者：谭鑫[1] 张宗平[1] 吴岫平[1] 叶锋[1] 程晓颖[1] 冯晓丽[1] 

机构地区：[1]广东省农垦中心医院脑外科,524002

出　　处：《中国保健营养（临床医学学刊）》2009年第6期63-64,共2页China Health Care Nutrtion

摘　　要：目的观察单唾液酸四己糖神经节苷脂钠联用醒脑静注射液治疗急性重型颅脑外伤的临床疗效。方法将140例重型颅脑外伤的患者随机分为三组，联合组（单唾液酸四己糖神经节苷脂钠联用醒脑静）51例，单用单唾液酸四己糖神经节苷脂钠组48例，单用醒脑静组41例，用药．10d为1个疗程。对三组患者治疗后的意识状态好转的起效时间及10、20d后神经功能评定、临床疗效的总有效率进行比较。结果联合组意识状态好转的起效时间、神经功能评定，临床疗效的总有效率均优于单唾液酸四己糖神经节苷脂钠组及醒脑静组（P〈0．05或P〈0．01）。结论单唾液酸四己糖神经节苷脂钠联用醒脑静注射液能显著提高急性重型颅脑外伤患者的临床疗效，无明显不良反应。Objective to observe and elucidate therapeutic efficacy by combining combinaMonosialotetrahexosylganlioside Sodium （GM-1 ） with Xingnaojing （XNJ） injection on acute severe traumatic brain injury （AS-TBI） . Methods： a total of 140 patients with acute severe traumatic cerebral injury were randomly divided into three groups, a mixed group of 51 patients treated with GM- 1 in combination with XNJ injection, moreover, a single group of 48 patients infused with GM-1, the rest of 41 patients received XNJ treatment, each time course of treatment is 10 days. The onset time of regaining consciousness, neurological assessment and total effective rate have to be measured and contrasted either 10 or 20 days after the beginning of therapy among these groups. Results： A statistically significant improvement of onset time of regaining consciousness, neurological evaluation and clinically total effective rate on AS-TBI who received combined treatment compared to either GM-1 group or XNJ group （ P〈0.05 or P〈0.01 ）. Conclusion： these data demonstrate that administration of GM-1 combined with XNJ achieves remarkable effectiveness; negative impact of this approach on AS-TBI treatment remained insignificant.

关 键 词：单唾液酸四己糖神经节苷脂钠 醒脑静注射液 急性重型颅脑外伤 

分 类 号：R651.1[医药卫生—外科学]