生物法合成L-草铵膦的研究进展  

Progresses in Biosynthesis of L-Phosphinothricin

作　　者：楼亿圆[1] 林志坚[1] 郑仁朝[1] 郑裕国[1] 

机构地区：[1]浙江工业大学生物工程研究所,杭州310014

出　　处：《现代农药》2009年第3期1-4,10,共5页MODERN AGROCHEMICALS

基　　金：国家重点基础研究发展规划项目(2007CB714306)

摘　　要：草铵膦是一种广谱、低毒、非选择性的除草剂,也是全球第二大转基因作物耐受除草剂,应用前景十分广阔。草铵膦具有两种对映异构体,但只有L-构型具有除草活性。全面综述了已报道的生物法制备单一手性对映体L-草铵膦的生产工艺,从起始原料和所用酶系2个方面进行分类。通过比较各生物法工艺的优缺点,探讨了生物法工业化生产L-草铵膦的可行性,并对其进一步的发展方向提出了展望。L-phosphinothricin is the active ingredient of the broad-spectrum, low toxic and nonselective herbicide glufosinate-ammonium, and also the second largest transgene crop resistant herbicide worldwide. Phosphinothricin consists of two isomers, but only the L-enantiomer has herbicidal activity. Biotechnological methods for preparation of optical pure L-phosphinothricin were reviewed in this article from the view of substrates and enzymes involved. Feasibility and development direction of industrial production of L-phosphinothricin by biotechnological methods was discussed on the basis of comparison of their advantages and disadvantages.

关 键 词：L-草铵膦 生物合成 手性对映体 

分 类 号：TQ457.29[化学工程—农药化工]