血浆D-二聚体和纤维蛋白原在兔脊髓缺血再灌注损伤中的意义  

Significance of plasma D-dimer and fibrinogen concentration in spinal cord ischemia-reperfusion injury in rabbits

作　　者：巩守平[1] 王文涛[1] 钟大林[1] 吕健[1] 吴锋[2] 车金[2] 僧志远[1] 贺西京 

机构地区：[1]西安交通大学医学院第二附属医院神经外科,陕西西安710004 [2]西安交通大学医学院血液病实验室,陕西西安710061 [3]第二附属医院骨外科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2009年第3期346-348,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的观察血浆D-二聚体和纤维蛋白原(FIB)在脊髓缺血再灌注损伤(SCIRI)中的变化,探讨D-二聚体和FIB在SCIRI中的意义。方法采用Zivin法建立家兔SCIRI模型,动态监测兔SCIRI缺血前即刻(10 min)、缺血45 min(Ⅰ45 min)、缺血再灌注后2 h(I/R2 h)、缺血再灌注后6 h(I/R6 h)、缺血再灌注后12 h(I/R12 h)5个时间点D-二聚体和FIB在血浆中含量的变化。结果血浆D-二聚体和FIB在Sham组和I/R组逐渐升高,均在缺血再灌注后2 h达到峰值,之后呈下降趋势。血浆D-二聚体于缺血再灌注后2 h和6 h时间点,I/R组与Sham组比较差异具有统计学意义(P<0.05);血浆FIB于缺血再灌注后2 h、6 h和12 h时间点,I/R组与Sham组比较差异具有统计学意义(P<0.05)。结论D-二聚体和FIB在SCIRI时显著增高,提示SCIRI与血液高凝和继发性纤溶状态密切相关。Objective To explore the changes and significance of plasma D-dimer and fibrinogen （FIB） in spinal cord ischemia-reperfusion injury （SCIRI）. Methods SCIRI models were established with Zivin method in rabbits. Plasma D-dimer and FIB were measured at five time points： at ischemia （10 min）, ischemia 45 rain （ I 45 min）, 2 h after ischemia-reperfusion （[/R 2 h）, 6 h after ischemia-reperfusion （I/R 6 h） and 12 h after ischemiareperfusion （I/R 12 h）. Results In both the sham group and I/R group, plasma D-dimer and FIB increased gradually and reached the peak value at I/R2h, then the decrease tendency was observed 2 hours later. There was a significant difference in D-dimer value between the sham and I/R groups at 2 h and 6 h time points （P〈0.05）. A significant difference in FIB was found between the sham and IR groups at 2 h, 6 h and 12 h time points （P〈0.05）. Conclusion The ovcrexpression of D-dimer and FIB in SCIRI showing hypercoagulability and secondary fibrinolysis may be closely related to SCIRI.

关 键 词：缺血再灌注 D-二聚体 纤维蛋白原 脊髓 

分 类 号：R651.2[医药卫生—外科学]