乌索酸对小鼠酒精性肝损伤的保护作用  

Protective Effect of Ursolic Acid Against Acute Alcoholic Liver Injury in Mice

作　　者：邱林立[1] 罗德生[2] 许娟[1] 潘代[1] 黄佳[1] 卢淑梅[1] 吴卉文[1] 

机构地区：[1]咸宁学院临床医学院,湖北咸宁437100 [2]咸宁学院基础医学院生物化学与分子生物学教研室

出　　处：《咸宁学院学报（医学版）》2009年第2期97-99,共3页Journal of Xianning Univarsity(medical Sciences)

基　　金：咸宁学院大学生科研基金资助课题

摘　　要：目的探讨乌索酸对小鼠酒精性肝损伤的影响。方法利用乙醇灌胃法建立小鼠急性肝损伤病理模型,分别以乌索酸按30mg/kg、60mg/kg小鼠口服给药,观察其对急性肝损伤小鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性及肝组织丙二醛(MDA)含量的影响。结果急性肝损伤模型组与空白对照组比较,各项指标差异均有显著性(P<0.01);乌索酸组与模型组比较,血清ALT、AST活性及肝组织MDA含量明显降低(P<0.05或P<0.01)。结论乌索酸对酒精所致的小鼠急性肝损伤具有保护作用。Objective To study the protective effect of ursolic acid （UA） on acute alcoholic liver injuryin mice. Ursolic acid was administrated ig to the mice with acute liver injury induced by alcohol. Colorimetric method was used to detect serum ALT, AST activities and liver MDA content. Results Compared with model group, ursolic acid could significantly decrease serum ALT, AST activities liver MDA content in mice with acute liver injury induced by alcohol （P 〈0.05 or P 〈0.01 ）. Conclusion Ursolic acid has protective effect agains acute liver injury induced by alcohol.

关 键 词：乌索酸 乙醇 丙氨酸氨基转移酶 天门冬氨酸氨基转移酶 丙二醛 急性肝损伤 

分 类 号：R965[医药卫生—药理学]