中药糖络宁对链脲佐菌素诱导糖尿病大鼠黏附分子的影响  

Effect of Tangluoning on adhesion molecules in streptozotocin induced diabetic rats

作　　者：高彦彬[1] 张涛静[1] 周晖[1] 关崧[1] 谢培凤[1] 商学征[1] 易文明[1] 盛彤[1] 张清怡[1] 

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《中华中医药杂志》2009年第7期843-845,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：教育部高等学校博士点基金资助项目(No.20050026002);国家自然科学基金资助项目(No.30873253)

摘　　要：目的:观察中药复方糖络宁对糖尿病大鼠黏附分子的影响。方法:采用链脲佐菌素糖尿病大鼠模型,造模成功后随机分为模型组、西药组及糖络宁组给药,共给药12周,给药结束后,利用流式细胞仪观察糖络宁对糖尿病大鼠黏附分子的影响。结果:与正常组大鼠比较,模型组糖尿病大鼠单个核细胞表面CD54、CD62P的表达明显增强(P<0.01);与模型组大鼠比较,糖络宁组大鼠CD54、CD62P表达显著下降(P<0.01),糖络宁组与西药组比较也有显著性下降(P<0.05)。结论:糖络宁可以有效降低糖尿病大鼠黏附分子CD54、CD62P的表达,这可能是糖络宁治疗糖尿病周围神经病变的机制之一。Objective： To investigate the effect of TangLuoNing （TLN） on adhesion molecules in streptozotocin （STZ） induced diabetic rats. Methods： STZ induced diabetic rats were randomized to diabetic model group, methycobal group, TLN group. The levels of CD54,CD62P of the animals were checked after 12 weeks＇ treatment. Results： Compare with normal rats group, CDs4,CD62P activities in all diabetic groups were significant higher （P〈0.01）. CD54,CD62P activities in TLN group and Methycobal group were lower. But only the activity of TLN group were significantly lower than the diatetic model group （P〈0.01）.The activity of TLN group was also significantly lower than the Methycobal group （P〈0.05）. Conclusion： TLN can reduce the adhesion molecule CD54 and CD62P activity in diabetic rats＇ sciatic serum which showed that the depression of vessel inflammation is one of main effect mechanism of TLN.

关 键 词：糖尿病大鼠 糖络宁 黏附分子 

分 类 号：R285.5[医药卫生—中药学]