活血通脉灵对实验性心肌缺血大鼠心肌损伤的抗炎保护作用  

Antiinflammatory protective mechanism of HuoXueTongMaiLing on experimental rats with myocardial ischem

作　　者：范冀湘[1] 高绍芳[2] 刘娜[2] 

机构地区：[1]岳阳职业技术学院临床医学系,岳阳414000 [2]河北医科大学研究生院,石家庄050000

出　　处：《中华中医药杂志》2009年第7期876-878,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨以浊毒理论为指导的活血通脉灵对实验性心肌缺血大鼠心肌损伤的抗炎保护作用机制。方法:将肢体Ⅱ导联心电图正常的50只Wistar雄性大鼠随机分为5组,每组10只(空白组、模型组、消心痛组及活血通脉灵高、低剂量治疗组)。空白组以普通饲料喂养;其余各组以高脂饲料喂养,形成高脂血症模型,在此基础上,皮下注射异丙肾上腺素,形成心肌缺血的复合模型。空白组和模型组分别灌等体积的生理盐水,其余各组分别灌消心痛、活血通脉灵高、低剂量进行治疗。采用血清学方法、放射免疫法等研究方法来观察各组心肌酶、炎症因子的变化,比较各组的差别。结果:活血通脉灵高、低剂量均能显著降低血清中心肌酶的含量(P<0.01),且能降低血清中肿瘤坏死因子和白介素-6的水平(P<0.01)。结论:活血通脉灵对大鼠心肌缺血而引起的心肌损伤具有保护作用,可改善心肌供血,有一定抗炎作用。Objectie： To study the protective effects and mechanism of Huoxuetongmailing（HXTML） on experimental myocardial ischemic rats by zhuodu. Methods 50 healthy male Wister rats were randomly divided into groups namely blank group, model group, Cedocard group, HXTMLmax and HXTMLmin group, 10 rats in each group. Each rat had been record Ⅱ electroca rdiographic（ECG） before the experiment. Hyperlipemic forage was feeded and ISO was subcutaneously injected into rats except Blank group to cause myocardial ischemia. Blank group and model group, respectively, the volume of normal saline irrigation, etc., and the rest of the group were irrigated isosorbide dinitrate, HXTMLmax and HXTMLmin dose treatmentAfter treatment, the myocardium zymogram（CK,CK-MB and LDH） and inflammatory factor were detected by modern medical method. Results ： HXTMLmax and HXTMLmin dose could significantly reduce the levels of serum enzymes（P〈0.01） and can reduce the serum TNF-α and IL-6 levels（P〈0.01）.Conclusion HXTML can alleviate the myocardial damage and protect myocardial tissue of rats. Furthermore and it has some particular effects on anti-inflammation.

关 键 词：活血通脉灵 心肌缺血 冠心病 炎症因子 异丙肾上腺素 

分 类 号：R285.5[医药卫生—中药学]