CPPS病人血清与前列腺按摩液CuZn-SOD和MDA检测及意义  

THE QUANTITATIVE DETERMINNATION AND ANALYSIS OF CuZn-SOD AND MDA IN SERUM AND EPS OF PATIENTS WITH CHRONIC PELVIC PAIN SYNDROME

作　　者：艾晓波[1] 侯四川[2] 刘忠强[3] 王沛涛[3] 于素清[4] 冯元法 仲伟明 

机构地区：[1]青岛大学医学院附属医院泌尿外科,山东青岛266003 [2]青岛市立医院泌尿外科 [3]青岛大学医学院附属医院低温医学科 [4]青岛大学医学院附属医院检验科 [5]青岛市阜外医院泌尿外科

出　　处：《青岛大学医学院学报》2009年第5期468-470,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的通过对慢性骨盆疼痛综合征(CPPS)病人和健康男性的血清和前列腺按摩液(EPS)中铜锌超氧化物歧化酶(CuZn-SOD)活力、丙二醛(MDA)含量测定,探讨其在CPPS诊断、治疗中的意义。方法将门诊确诊的40例CPPS病人分为炎性组和非炎性组,以20例健康男性为对照组,采用黄嘌呤氧化酶法测定CuZn-SOD活力,硫代巴比妥酸(TBA)法测定MDA含量。结果各组血清中CuZn-SOD活力比较差异无显著性(P>0.05)。炎性组及非炎性组血清中MDA含量明显高于对照组(F=25.70,q=8.21、9.26,P<0.01),炎性组与非炎性组间比较差异无显著性(P>0.05)。炎性组EPS中CuZn-SOD活力明显低于非炎性组及对照组(F=34.78,q=9.30、10.93,P<0.01);非炎性组与对照组间比较差异无显著性(P>0.05)。炎性组EPS中MDA含量明显高于非炎性组及对照组(F=441.63,q=35.73、37.03,P<0.01);非炎性组与对照组之间比较差异无显著性(P>0.05)。结论炎性CPPS病人前列腺氧化应激水平高于健康男性,非炎性CPPS病人前列腺氧化应激水平与健康男性无明显差别;血清及EPS中CuZn-SOD、MDA水平可作为CPPS诊断和判断疗效的有意义的辅助指标,SOD制剂在CPPS的治疗中可能具有重要作用。Objective To determine the levels of CuZn SOD and MDA in serum and EPS in patients with chronic pelvic pain syndrome （CPPS） and explore their significance in the diagnosis and treatment of this condition. Methods Forty outpatients confirmed as having CPPS were divided into inflammatory group and non inflammatory group and 20 healthy served as the control. Xanthine Oxidase method was applied to determine the content of CuZn-SOD and TBA method to determine the level of MDA. Results The levels of CuZn-SOD in serum among the three groups were not significantly different （P〉0.05）. The serum levels of MDA in CPPS patients were significantly higher than that of the control （F=25.70;q=8.21,9.26; P〈0.01）, but no significant difference was noted between the inflammatory and non inflammatory group （P〉0.05）. The vigour of CuZn SOD in the EPS of the inflammatory group was markedly lower than that in the non-inflammatory group and the control （F=34.78;q=9.30,10.93; P〈0.01）, but no significant difference was noted between the non-inflammatory group and the control （P〉0.05）. The MDA in EPS of the inflammatory group was dramatically higher than that in the non inflammatory and the control （F 441.63;q 35.73, 37.03;P（0.01）, but no significant difference between the non inflammatory and the control （P〉0.05）. Conclusion The oxi dative stress of EPS patients with inflammatory CPPS is stronger than that of the healthy adults, while there is no significant difference of the oxidative stress between patients with the non inflammatory CPPS and the health young man. Measurements of the levels of CuZn-SOD and MDA, both in serum and EPS, can serve as valuable parameters in the diagnosis and assessment of the therapy of CPPS.

关 键 词：慢性骨盆疼痛综合征 铜锌超氧化物歧化酶 丙二醛 

分 类 号：R697.33[医药卫生—泌尿科学]